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Embryotoxic evaluation of bis(tri-n-butyltin)oxide (TBTO) in mice

S Baroncelli1, D Karrer, P G Turillazzi

  • 1Laboratorio di Tossicologia Comparata ed Ecotossicologia, Istituto Superiore di Sanità, Rome, Italy.

Toxicology Letters
|February 1, 1990
PubMed

Insights

Bis(tri-n-butyltin)oxide (TBTO) exposure during pregnancy in mice caused significant maternal weight reduction and embryotoxicity. Organ weights were affected, with spleen weight decreasing and placental weight increasing dose-dependently.

Area of Science:

  • Toxicology
  • Developmental Biology
  • Reproductive Toxicology

Background:

  • Bis(tri-n-butyltin)oxide (TBTO) is an organotin compound with known toxicological properties.
  • Understanding the developmental toxicity of environmental contaminants is crucial for public health.

Purpose of the Study:

  • To investigate the embryotoxic and developmental effects of bis(tri-n-butyltin)oxide (TBTO) in pregnant mice.
  • To assess the impact of TBTO on maternal and fetal health during gestation.

Main Methods:

  • Pregnant mice were administered varying doses of bis(tri-n-butyltin)oxide (TBTO) during critical gestational periods (days 6-15).
  • Maternal body weight gain and organ weights (spleen, placenta) were measured.
  • Embryotoxicity was assessed at gestational day 17.

Main Results:

  • A significant reduction in maternal body weight gain was observed at the highest TBTO dose.
  • Bis(tri-n-butyltin)oxide (TBTO) demonstrated high embryotoxicity.
  • A dose-related decrease in spleen weight and a dose-dependent increase in placental weight were noted.

Conclusions:

  • Bis(tri-n-butyltin)oxide (TBTO) poses a significant risk to maternal health and embryonic development.
  • Organ weight changes in spleen and placenta indicate potential toxicological mechanisms of TBTO.
  • Further research is warranted to elucidate the specific pathways of TBTO-induced developmental toxicity.

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