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Vibrio fluvialis in patients with diarrhea, Kolkata, India

Goutam Chowdhury1, Gururaja P Pazhani, Devarati Dutta

  • 1National Institute of Cholera and Enteric Diseases, P-33, CIT Road, Scheme XM, Beliaghata, Kolkata 700010, India.

Emerging Infectious Diseases
|October 25, 2012
PubMed

Insights

A study in Kolkata, India, found 131 Vibrio fluvialis strains in diarrhea patients. Many strains carried virulence genes, offering insights into Vibrio fluvialis pathogenicity.

Area of Science:

  • Microbiology
  • Infectious Diseases
  • Gastroenterology

Background:

  • Diarrheal diseases remain a significant global health concern.
  • Vibrio species are known etiological agents of gastroenteritis.
  • The specific role of Vibrio fluvialis in diarrheal illness requires further elucidation.

Purpose of the Study:

  • To identify and characterize Vibrio fluvialis isolates from patients with diarrhea in Kolkata, India.
  • To investigate the prevalence of V. fluvialis as a sole pathogen in diarrheal cases.
  • To explore potential virulence factors associated with V. fluvialis pathogenicity.

Main Methods:

  • Bacterial isolation and identification of Vibrio species from stool samples.
  • Molecular detection of virulence genes, including hemolysin and metalloprotease.
  • Clinical data review to determine V. fluvialis as the sole identified pathogen.

Main Results:

  • 131 strains of Vibrio fluvialis were identified from 400 nonagglutinating Vibrio spp. isolates.
  • Vibrio fluvialis was the sole pathogen in 43 of the diarrheal cases.
  • The majority of V. fluvialis strains harbored genes for hemolysin and metalloprotease.

Conclusions:

  • Vibrio fluvialis is a notable cause of diarrhea in Kolkata, India.
  • The presence of hemolysin and metalloprotease genes suggests their contribution to V. fluvialis pathogenicity.
  • Further research is warranted to fully understand the mechanisms of V. fluvialis-associated disease.

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