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High plasma adiponectin concentration is associated with all-cause mortality in patients with carotid atherosclerosis

Jonas Persson1, Lasse Folkersen, Johan Ekstrand

  • 1Division of Cardiovascular Medicine, Department of Clinical Sciences, Karolinska Institutet, Danderyd University Hospital, Sweden. jonas.persson@ds.se

Atherosclerosis
|October 25, 2012
PubMed

Insights

High adiponectin levels are linked to increased mortality in patients with carotid artery stenosis. However, adiponectin did not predict recurrent ischemic cardiovascular events in this patient group.

Area of Science:

  • Cardiovascular Medicine
  • Endocrinology
  • Biomarkers

Background:

  • The prognostic value of adiponectin in carotid artery disease remains unclear.
  • Investigating adiponectin's role in mortality and ischemic events is crucial for risk stratification.

Purpose of the Study:

  • To determine if plasma adiponectin concentrations predict mortality and recurrent ischemic cardiovascular events in patients undergoing carotid endarterectomy.

Main Methods:

  • A cohort of 292 patients undergoing carotid endarterectomy was studied.
  • Plasma adiponectin levels were measured at baseline.
  • Cox regression models were used to assess the risk of mortality and ischemic events over a median follow-up of 5.2 years.

Main Results:

  • High adiponectin levels were independently associated with increased mortality (HR per SD increase: 1.73).
  • Adiponectin was not significantly associated with recurrent ischemic cardiovascular events (HR per SD increase: 0.96).
  • Factors like age, type 2 diabetes mellitus, and coronary heart disease were also associated with mortality.

Conclusions:

  • Elevated plasma adiponectin is associated with mortality in patients with carotid artery stenosis undergoing surgery.
  • Adiponectin may serve as a mortality biomarker but not for ischemic events in this population.
  • Further research is needed to validate adiponectin's role as a prognostic biomarker.
Abstract

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