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Labeling DNA Probes

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Related Experiment Video

Updated: May 17, 2026

Genetically-encoded Molecular Probes to Study G Protein-coupled Receptors

Genetically-encoded Molecular Probes to Study G Protein-coupled Receptors

Published on: September 13, 2013

Epigenetic chemical probes.

S Müller¹, P J Brown

¹Structural Genomics Consortium, University of Oxford, Oxford, UK.

Clinical Pharmacology and Therapeutics

|October 25, 2012

Summary

Epigenetic gene expression is controlled by DNA methylation and histone modifications. Over 400 epigenetic targets have been identified in the last decade, influencing gene expression changes.

Area of Science:

Molecular Biology
Genetics
Epigenetics

Background:

Gene expression is regulated by epigenetic mechanisms.
Key epigenetic mechanisms include DNA methylation and histone modification.
These modifications alter gene expression without changing the underlying DNA sequence.

Purpose of the Study:

To review the advancements in understanding epigenetic control of gene expression.
To highlight the discovery of numerous epigenetic targets.
To discuss the role of DNA methylation and histone modification in gene expression regulation.

Main Methods:

Literature review of epigenetic research over the past 10 years.
Identification and categorization of epigenetic targets.
Analysis of the mechanisms linking epigenetic modifications to gene expression changes.

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Sequence-specific Labeling of Nucleic Acids and Proteins with Methyltransferases and Cofactor Analogues

Sequence-specific Labeling of Nucleic Acids and Proteins with Methyltransferases and Cofactor Analogues

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Last Updated: May 17, 2026

Genetically-encoded Molecular Probes to Study G Protein-coupled Receptors

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Published on: September 13, 2013

In Vitro Chemical Mapping of G-Quadruplex DNA Structures by Bis-3-Chloropiperidines

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Published on: May 12, 2023

Sequence-specific Labeling of Nucleic Acids and Proteins with Methyltransferases and Cofactor Analogues

Sequence-specific Labeling of Nucleic Acids and Proteins with Methyltransferases and Cofactor Analogues

Published on: November 22, 2014

Main Results:

Significant acceleration in the discovery of epigenetic targets over the last decade.
Identification of over 400 domains involved in epigenetic regulation.
Elucidation of the roles of DNA methylation and histone modification in gene expression.

Conclusions:

Epigenetic mechanisms, particularly DNA methylation and histone modification, are crucial for gene expression control.
The field has made substantial progress in identifying epigenetic targets.
Further research continues to uncover the complex interplay between epigenetics and gene expression.