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The angiotensin-converting enzyme 2/angiotensin-(1-7)/Mas receptor axis: a potential target for treating thrombotic

Rodrigo A Fraga-Silva1, Danielle G Da Silva, Fabrizio Montecucco

  • 1Institute of Bioengineering, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland.

Thrombosis and Haemostasis
|October 25, 2012
PubMed

Insights

The Angiotensin-Converting Enzyme 2 (ACE2)/Angiotensin-(1-7)/Mas receptor axis shows protective effects against thrombosis. This system presents a promising therapeutic target for preventing and treating thrombotic events like stroke and heart attack.

Area of Science:

  • Cardiovascular Science
  • Pharmacology
  • Physiology

Background:

  • Thrombotic events remain a leading cause of death globally, despite advances in drug treatments.
  • Identifying novel therapeutic targets for thrombotic diseases is crucial.

Purpose of the Study:

  • To review recent findings on the role of the ACE2/Angiotensin-(1-7)/Mas axis in hemostasis.
  • To explore the therapeutic potential of this axis in managing thrombotic disorders.

Main Methods:

  • Narrative review of existing literature.
  • Focus on studies investigating the counter-regulatory renin-angiotensin system (RAS).

Main Results:

  • The ACE2/Angiotensin-(1-7)/Mas axis demonstrates protective effects against thrombosis.
  • Evidence suggests this axis influences the hemostatic process.

Conclusions:

  • The ACE2/Angiotensin-(1-7)/Mas axis is a significant factor in hemostasis.
  • This axis represents a promising therapeutic target for thrombotic diseases.

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