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The Tumor Microenvironment

The Tumor Microenvironment

Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...

The Tumor Microenvironment

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Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...

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Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
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Tumor Progression

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Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
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Related Experiment Video

Updated: May 17, 2026

Identifying Bone Marrow Microenvironmental Populations in Myelodysplastic Syndrome and Acute Myeloid Leukemia

Identifying Bone Marrow Microenvironmental Populations in Myelodysplastic Syndrome and Acute Myeloid Leukemia

Published on: November 10, 2023

Bone marrow microenvironment in multiple myeloma progression.

S Manier¹, A Sacco, X Leleu

¹Dana-Farber Cancer Institute, Department of Medical Oncology, Harvard Medical School, 450 Brookline Avnue, HIM 246, Boston, MA 02215, USA.

Journal of Biomedicine & Biotechnology

|October 25, 2012

Summary

This summary is machine-generated.

The bone marrow microenvironment supports multiple myeloma (MM) progression by influencing cancer cell survival and drug resistance. Understanding this niche is key to developing new MM therapies.

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Multimodal Bioluminescent and Positronic-emission Tomography/Computational Tomography Imaging of Multiple Myeloma Bone Marrow Xenografts in NOG Mice

Multimodal Bioluminescent and Positronic-emission Tomography/Computational Tomography Imaging of Multiple Myeloma Bone Marrow Xenografts in NOG Mice

Published on: January 7, 2019

Area of Science:

Oncology
Cell Biology
Hematology

Background:

The bone marrow (BM) microenvironment is crucial for multiple myeloma (MM) biology.
This niche influences malignant plasma cell differentiation, migration, proliferation, survival, and drug resistance.

Purpose of the Study:

To explore the role of the BM microenvironment in MM progression.
To discuss the interaction between malignant plasma cells and the BM niche.

Main Methods:

Review of existing literature on the BM microenvironment in MM.
Analysis of cellular and noncellular components of the BM niche.

Main Results:

The BM niche, comprising cellular and noncellular elements, significantly impacts MM progression.
Interactions within the niche facilitate malignant plasma cell homing and contribute to the pre-metastatic niche concept.

Conclusions:

The BM microenvironment is a critical factor in multiple myeloma pathogenesis.
Targeting the BM niche interactions may offer novel therapeutic strategies for MM.