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Related Concept Videos

MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA ends...
MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...
MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA ends...

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Related Experiment Video

Updated: May 17, 2026

MicroRNA Amplification and Recognition through Locked-nucleic-acid In situ Hybridization as a Novel Detection and Quantification Method
09:06

MicroRNA Amplification and Recognition through Locked-nucleic-acid In situ Hybridization as a Novel Detection and Quantification Method

Published on: October 7, 2025

miRandola: extracellular circulating microRNAs database.

Francesco Russo1, Sebastiano Di Bella, Giovanni Nigita

  • 1Department of Clinical and Molecular Biomedicine, University of Catania, Catania, Italy.

Plos One
|October 25, 2012
PubMed
Summary
This summary is machine-generated.

Extracellular microRNAs (miRNAs) are promising cancer biomarkers found in body fluids. The miRandola database offers a comprehensive classification of these circulating miRNAs, aiding in understanding their biological functions and disease connections.

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Last Updated: May 17, 2026

MicroRNA Amplification and Recognition through Locked-nucleic-acid In situ Hybridization as a Novel Detection and Quantification Method
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Published on: October 7, 2025

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Published on: March 14, 2019

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Bioinformatics

Background:

  • MicroRNAs (miRNAs) are small noncoding RNAs regulating gene expression.
  • Dysregulated miRNAs are implicated in cancer and show potential as diagnostic and prognostic biomarkers.
  • Circulating miRNAs exist in extracellular fluids and are stable, making them ideal for blood-based diagnostics.

Purpose of the Study:

  • To present miRandola, a manually curated database classifying extracellular circulating miRNAs.
  • To connect miRandola with the miRò knowledge base for functional and phenotypic inference.
  • To provide a comprehensive resource for biomedical research on circulating miRNAs.

Main Methods:

  • Manual curation of extracellular circulating miRNA data.
  • Classification of miRNAs based on their extracellular form (miRNA-Ago2, miRNA-exosome, miRNA-HDL, miRNA-circulating).
  • Integration with the miRò miRNA knowledge base.

Main Results:

  • The miRandola database contains 2132 entries, including 581 unique mature miRNAs across 21 sample types.
  • miRNAs are categorized into four extracellular forms: miRNA-Ago2 (173 entries), miRNA-exosome (856 entries), miRNA-HDL (20 entries), and miRNA-circulating (1083 entries).
  • The database facilitates the inference of biological functions and phenotype connections for circulating miRNAs.

Conclusions:

  • The miRandola database is a valuable, comprehensive resource for studying extracellular circulating miRNAs.
  • This classification aids in understanding the role of circulating miRNAs in various biological processes and diseases.
  • The integration with miRò enhances the utility of miRandola for functional and clinical research.