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Updated: May 17, 2026
Demonstration of the Rat Ischemic Skin Wound Model
Published on: April 1, 2015
A skin fixation method for decreasing the influence of wound contraction on wound healing in a rat model
Seong Hwan Bae1, Yong Chan Bae, Su Bong Nam
1Department of Plastic and Reconstructive Surgery, Pusan National University School of Medicine, Busan, Korea.
Background:
The elasticity of the back skin of the rat reduced the tension around wounds during the wound healing process in that region, and thus activates wound contraction. The authors proposed two skin fixation methods using readily available materials to decrease the influence of wound contraction on wound healing and designed an experiment to determine their effects.
Methods:
The authors made 36 skin wounds on the backs of 18 rats, and they divided them into three groups. Each group was treated with three different kinds of dressing materials, each with different skin fixing characteristics. Group A was a control group. Group B and group C were dressed by the first and the second skin fixation method. We measured the areas of the wounds post-surgically and calculated the wound area reduction rates.
Results:
The two skin fixation methods both reduced the effect of wound contraction compared to the control group. Each of the two methods had different outcomes in reducing wound contraction.
Conclusions:
The experiment demonstrated significant differences among the wound areas and the wound area reduction rates of the three groups as a result of differences in the degree of wound contraction. To obtain accurate results from wound healing experiments, appropriate skin fixation methods must be adopted.
