Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Blood Transfusion and Agglutination02:45

Blood Transfusion and Agglutination

Blood transfusion is a therapeutic measure to restore the blood volume after extensive blood loss due to an accident or a medical procedure. Blood transfusion involves drawing a certain amount of blood from a suitable donor and infusing it into the recipient.
History
The history of blood transfusion dates back to the 17th century, when early attempts were made in animals. In 1818 James Blundell, a British doctor, performed the first successful human blood transfusion. Later in 1900, Karl...
Blood Transfusion01:15

Blood Transfusion

Blood transfusion is a critical medical procedure that saves lives and treats various medical conditions. It involves transferring blood from a donor to a recipient. This process requires a thorough understanding of the ABO blood group system and its associated antigens and antibodies.
Blood Transfusion Overview
A blood transfusion is a medical procedure used to replace blood lost due to injury, surgery, or to treat conditions such as anemia or cancer. During a transfusion, donor blood is...
Rh Blood Group01:19

Rh Blood Group

The Rhesus (Rh) antigen is crucial in determining blood groups and ensuring compatibility during blood transfusions.
Drug Dosing: Infants and Children01:29

Drug Dosing: Infants and Children

Pediatric patient dosages diverge from adults due to disparities in body surface area, total body water, and extracellular fluid per kilogram of body weight. The dosing regimen considers the variations in pharmacokinetics and pharmacology across distinct age groups, encompassing preterm newborns, infants, young children, older children, and adolescents. Calculation of pediatric patient doses is predicated on determining body surface area, which exhibits a superior correlation with the child's...
Pharmacokinetics in Pediatric Patients: Drug Distribution01:17

Pharmacokinetics in Pediatric Patients: Drug Distribution

Drug distribution in the pediatric population exhibits unique challenges and considerations due to the physiological differences between children, particularly neonates and infants, and adults. A crucial aspect of pediatric pharmacology is understanding how these differences impact the pharmacokinetics of various drugs, necessitating age-specific dosing strategies to ensure efficacy and safety.Neonates and infants have a higher total body water content, ~75%–90% of their body weight, compared...
Pharmacokinetics in Pediatric Patients: Drug Excretion01:26

Pharmacokinetics in Pediatric Patients: Drug Excretion

In pediatric medicine, understanding the renal function and drug elimination nuances is crucial for administering safe and effective treatments. Newborns, in particular, display markedly slower renal functions than adults, profoundly affecting how drugs are cleared from their bodies. This slower drug clearance requires clinicians to extend the dosing intervals for many medications to prevent drug accumulation and toxicity while ensuring therapeutic efficacy.One key area where these adjustments...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Diversity, spatiotemporal distribution, and host associations of flea species, with detection of co-infection with Rickettsia asembonensis and Wolbachia spp.

Journal of medical entomology·2026
Same author

Drugs to improve anaemia, quality of life, and physical function in people with myelodysplastic syndromes (MDS).

The Cochrane database of systematic reviews·2026
Same author

Annotated datasets for waste electrical and electronic equipment identification and battery detection and classification.

Scientific data·2026
Same author

Area level measures of socioeconomic deprivation and their impact on very preterm birth and very preterm birth outcomes: A retrospective cohort study.

Journal of perinatology : official journal of the California Perinatal Association·2026
Same author

Femoral Neck System in Pauwell III Femoral Neck Fractures: A Bibliometric Analysis and Review.

Cureus·2026
Same author

Adaptive reinforcement learning for lithography optimization: a scalable AI-driven solution for next-generation semiconductor manufacturing.

Scientific reports·2026

Related Experiment Video

Updated: May 17, 2026

Transcutaneous Microcirculatory Imaging in Preterm Neonates
06:27

Transcutaneous Microcirculatory Imaging in Preterm Neonates

Published on: December 31, 2015

How we decide when a neonate needs a transfusion.

Vidheya Venkatesh1, Rizwan Khan, Anna Curley

  • 1Neonatal Intensive Care Unit, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.

British Journal of Haematology
|October 26, 2012
PubMed
Summary
This summary is machine-generated.

This study reviews transfusion guidelines for neonates, focusing on red blood cells, platelets, and fresh frozen plasma (FFP). Evidence supports lower hemoglobin thresholds for red cell transfusions, while FFP use should prioritize bleeding cases.

Related Experiment Videos

Last Updated: May 17, 2026

Transcutaneous Microcirculatory Imaging in Preterm Neonates
06:27

Transcutaneous Microcirculatory Imaging in Preterm Neonates

Published on: December 31, 2015

Area of Science:

  • Neonatal Medicine
  • Hematology
  • Pediatric Critical Care

Background:

  • Transfusion decisions in neonates involve assessing anemia causes, alternatives, necessity, and risks.
  • Recent trials on red cell transfusions offer evidence-based practice insights but raise questions on neurological outcomes with lower thresholds.
  • Current practices for platelet and fresh frozen plasma (FFP) transfusions in neonates are evolving.

Purpose of the Study:

  • To provide evidence-based guidance on transfusion practices for neonates.
  • To clarify appropriate hemoglobin thresholds for red blood cell transfusions.
  • To define optimal strategies for platelet and FFP transfusions in neonates.

Main Methods:

  • Review of recent clinical trials and existing literature on neonatal transfusion practices.
  • Analysis of hemoglobin (Hb) concentration thresholds for red cell transfusions in different neonatal subgroups.
  • Evaluation of evidence for prophylactic versus therapeutic use of platelet and FFP transfusions.

Main Results:

  • Red cell transfusions are recommended for premature neonates on mechanical ventilation with Hb <120 g/l.
  • Lower Hb thresholds (70-100 g/l) are suggested for oxygen-dependent or late anemia.
  • Evidence for prophylactic platelet transfusions is lacking; thresholds are shifting to 20-30 × 10(9) /l.
  • Therapeutic use of FFP for bleeding is preferred over prophylactic use in stable neonates.

Conclusions:

  • Transfusion guidelines for neonates require careful consideration of specific clinical situations and evidence.
  • Lower hemoglobin thresholds for red cell transfusions may be appropriate in certain neonatal populations.
  • Fresh frozen plasma should be reserved for neonates experiencing active bleeding.