Related Experiment Video
Updated: May 17, 2026

Prediction of HIV-1 Coreceptor Usage (Tropism) by Sequence Analysis using a Genotypic Approach
Published on: December 1, 2011
Concordance between HIV-2 genotypic coreceptor tropism predictions based on plasma RNA and proviral DNA
Benoit Visseaux1, Charlotte Charpentier, Audrey Taieb
1Laboratoire de Virologie, Assistance Publique-Hôpitaux de Paris AP-HP, Groupe Hospitalier Bichat-Claude Bernard, HUPNVS, Université Paris Diderot, Paris 7, PRES Sorbonne Paris Cité, Paris, France. benoit.visseaux@bch.aphp.fr
Abstract:
In this study, assessing HIV-2 tropism among 43 paired plasma/peripheral blood mononuclear cell specimens, the concordance between proviral DNA and plasma RNA genotypic tropism prediction was 74%. All the discordances were attributable to the prediction of R5 in RNA and X4/dual-mixed in DNA. HIV-2 genotypic tropism test based on proviral DNA is a suitable tool for tropism determination in HIV-2-infected patients with low or undetectable viral load.

