Epigenetic regulation of brain-derived neurotrophic factor: implications in neurodevelopment and behavior
1Psychiatric and Neurodevelopmental Genetics Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02115, USA. bdschanker@gmail.com
The Behavioral and Brain Sciences
|October 26, 2012
Abstract:
Several recent research findings have implicated brain-derived neurotrophic factor (BDNF) as a mediator of neuronal plasticity. The BDNF gene is under extensive epigenetic regulation, which modulates how much or how little environmental experiences become encoded within neurons and neural circuits. Future scientific progress within the postgenomic paradigm requires elucidation of the functional trajectory in neogenetic and environment interactions.
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