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Updated: May 17, 2026

A Quantitative Measurement of Reactive Oxygen Species and Senescence-associated Secretory Phenotype in Normal Human Fibroblasts During Oncogene-induced Senescence
13:59

A Quantitative Measurement of Reactive Oxygen Species and Senescence-associated Secretory Phenotype in Normal Human Fibroblasts During Oncogene-induced Senescence

Published on: August 12, 2018

Controversial aspects of oncogene-induced senescence

Anna Bianchi-Smiraglia1, Mikhail A Nikiforov

  • 1Department of Cell Stress Biology, Roswell Park Cancer Institute, Buffalo, NY, USA.

Cell Cycle (Georgetown, Tex.)
|October 26, 2012
PubMed

Insights

Oncogene-induced senescence (OIS) is a cellular safeguard against cancer. This review explores debated roles of tumor suppressors, DNA damage, and varied OIS types in normal cells.

Area of Science:

  • Cellular Biology
  • Cancer Research
  • Molecular Oncology

Background:

  • Oncogene-induced senescence (OIS) acts as a crucial tumor-suppressive mechanism.
  • It prevents uncontrolled cell proliferation triggered by oncoprotein activation in normal cells.
  • RAS and RAF proteins are commonly cited inducers of OIS.

Purpose of the Study:

  • To review controversial aspects of RAS- or RAF-induced senescence.
  • To investigate the significance of tumor suppressors in OIS.
  • To examine the role of DNA damage in OIS and explore potential variations in OIS types.

Main Methods:

  • Literature review and analysis of existing studies on OIS.
  • Examination of data concerning RAS and RAF signaling pathways.
  • Comparative analysis of OIS in different normal cell types.

Main Results:

  • The review highlights ongoing debates regarding the necessity of tumor suppressors for OIS.
  • It discusses the complex relationship between DNA damage and the induction of senescence.
  • Evidence suggests that OIS may not be a uniform process, with potential for different subtypes.

Conclusions:

  • The precise mechanisms and requirements for OIS, particularly concerning tumor suppressors and DNA damage, require further elucidation.
  • Understanding the heterogeneity of OIS is critical for its implications in cancer prevention and therapy.

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