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Related Experiment Videos

Concentration of bone elements in osteoporosis.

M F Baslé1, Y Mauras, M Audran

  • 1Laboratory of Histology and Embryology, Faculty of Medicine, Angers, France.

Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research
|January 1, 1990
PubMed
Summary

Osteoporosis leads to decreased bone density, but this study found no changes in bone mineral element concentrations. Bone density loss in osteoporosis is linked to reduced bone mass, not altered mineral composition.

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Area of Science:

  • Biomineralization
  • Bone Physiology
  • Osteoporosis Research

Background:

  • Decreased bone density in aging and osteoporosis is linked to reduced bone mass.
  • The role of bone mineral phase changes and elemental concentration in osteoporosis requires further investigation.

Purpose of the Study:

  • To investigate if bone mineral loss in osteoporosis is due to reduced bone mass or altered elemental concentrations in bone tissue.
  • To determine the concentration of various elements in the cortical bone of osteoporotic and control subjects.

Main Methods:

  • Analysis of iliac crest bone biopsies from 33 subjects (12 controls, 21 with severe osteoporosis).
  • Quantification of calcium and phosphorus using energy-dispersive X-ray microanalysis and ICP-OES.
  • Measurement of Na, K, Mg, Cu, Zn, Fe, Sr, Al, B, and Si via ICP-OES.

Related Experiment Videos

  • Determination of fluorine and lead concentrations using specific ion electrode and atomic absorption spectrometry, respectively.

    • Main Results:

    • No significant age-dependent variations in Ca, P, or other elemental concentrations were observed in mineralized bone tissue for either group.
    • Elemental concentrations in bone tissue did not differ between control and osteoporotic subjects.
    • Bone density reduction in osteoporosis appears directly related to bone mass changes.

    Conclusions:

    • The decrease in bone density observed in osteoporosis is primarily associated with a reduction in bone mass.
    • There are no detectable changes in the concentration of mineral elements within the bone tissue itself in osteoporosis.