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Related Concept Videos

Nervous Tissue: Glial Cells01:31

Nervous Tissue: Glial Cells

Glia, or neuroglia, are vital support cells that assist neurons in their functions. The term "glia" originates from the Greek word for "glue," reflecting their role in holding the nervous system together. These cells can be categorized into six types: four in the central nervous system (CNS) and two in the peripheral nervous system (PNS).
The CNS glial cell includes the astrocytes, the oligodendrocytes, the microglia, and the ependymal cells.
Astrocytes are star-shaped glial cells that interact...
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Introduction to Fibroblasts01:09

Introduction to Fibroblasts

Rudolph Virchow discovered spindle-shaped cells called fibroblasts in 1858. Inactive fibroblasts, called fibrocytes, become activated by various stimuli, such as growth factors and inflammatory cytokines. Activated fibroblasts play a crucial role in wound healing, inflammation, formation of new blood vessels, and cancer progression. Uncontrolled activation of fibroblasts results in fibrosis, the excess deposition of fibrous tissue, which can lead to scarring and affect normal organs. This...
Neurogenesis and Regeneration of Nervous Tissue01:15

Neurogenesis and Regeneration of Nervous Tissue

In the CNS, neurogenesis, the birth of new neurons from stem cells, is limited to the hippocampus in adults. In other regions of the brain and spinal cord, neurogenesis is almost non-existent due to inhibitory influences from neuroglia, especially oligodendrocytes, and the absence of growth-stimulating cues. The myelin produced by oligodendrocytes in the CNS inhibits neuronal regeneration. Furthermore, astrocytes proliferate rapidly after neuronal damage, forming scar tissue that physically...
Nervous Tissue: Myelin01:25

Nervous Tissue: Myelin

The myelin sheath is a multilayered lipid and protein covering that insulates the axon of a neuron, enhancing the speed of nerve impulse conduction. Axons without this sheath are referred to as unmyelinated. Two types of neuroglia, Schwann cells in the peripheral nervous system (PNS) and oligodendrocytes in the central nervous system (CNS) are responsible for producing myelin sheaths.
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Connective Tissue Cell Types01:22

Connective Tissue Cell Types

Connective tissue develops from the mesoderm of a developing embryo and consists of cells, fibers, and ground substance: a gel-like material containing large complexes of carbohydrates and proteins. Connective tissue was first identified as a separate tissue family in the 18th century, and Johannes Peter Muller coined the term connective tissue.
Fat cells (adipocytes), smooth muscle cells (myoblasts), and bone cells (osteoblasts) are some connective tissue cell types. Some immune system cells...

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Related Experiment Video

Updated: May 17, 2026

Purification of Fibroblasts and Schwann Cells from Sensory and Motor Nerves in Vitro
08:16

Purification of Fibroblasts and Schwann Cells from Sensory and Motor Nerves in Vitro

Published on: May 20, 2020

Endoneurial fibroblast-like cells.

Laurence Richard1, Piotr Topilko, Laurent Magy

  • 1National Referral Center for Rare Peripheral Neuropathies, Department of Neurology, Centre Hospitalier Universitaire, Limoges, Paris, France.

Journal of Neuropathology and Experimental Neurology
|October 26, 2012
PubMed
Summary
This summary is machine-generated.

Endoneurial fibroblast-like cells (EFLCs) originate from the neural crest, explaining their diverse functions and roles in disease. This review consolidates current knowledge on EFLC origins, functions, and pathology.

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Analyzing Murine Schwann Cell Development Along Growing Axons
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Analyzing Murine Schwann Cell Development Along Growing Axons
09:46

Analyzing Murine Schwann Cell Development Along Growing Axons

Published on: November 21, 2012

Area of Science:

  • Neuroscience
  • Cell Biology
  • Histology

Background:

  • Endoneurial fibroblast-like cells (EFLCs) have been recognized for decades but their embryological origin, functions, and pathological roles remain poorly understood.
  • Existing hypotheses regarding EFLC origin lack definitive evidence.
  • Understanding EFLCs is crucial for comprehending peripheral nerve biology and pathology.

Purpose of the Study:

  • To review the current literature and personal observations on the origin, functions, and pathology of endoneurial fibroblast-like cells (EFLCs).
  • To consolidate evidence supporting the neural crest origin of EFLCs.
  • To elucidate the multifaceted roles of EFLCs in normal physiology and disease states.

Main Methods:

  • Literature review of studies on EFLC embryology, function, and pathology.
  • Analysis of personal observations and data related to EFLCs.
  • Synthesis of information to support the neural crest origin hypothesis.

Main Results:

  • Data supports the hypothesis that EFLCs are of neural crest origin.
  • This neural crest lineage may explain the diverse biological functions of EFLCs.
  • EFLCs are implicated in collagen synthesis, phagocytosis, inflammatory responses, and immune surveillance.

Conclusions:

  • The neural crest origin of EFLCs is supported by current evidence.
  • EFLCs possess multiple biological functions, including roles in collagen synthesis, immune surveillance, and inflammatory responses.
  • Further research into EFLC pathology is warranted given their involvement in disease processes.