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Continued statin therapy could improve the outcome after spontaneous intracerebral hemorrhage

J H Tapia-Pérez1, R Rupa, R Zilke

  • 1Klinik für Neurochirurgie, Otto-von-Guericke Universität, Leipziger Strasse 44, 39120 Magdeburg, Germany. jorge.tapia@med.ovgu.de

Neurosurgical Review
|October 26, 2012
PubMed

Insights

Continuing statin therapy after spontaneous intracerebral hemorrhage (ICH) showed reduced mortality and improved neurological outcomes. This neuroprotective effect may be linked to statins' immunomodulatory properties.

Area of Science:

  • Neurology
  • Pharmacology
  • Cardiology

Background:

  • Spontaneous intracerebral hemorrhage (ICH) is a severe neurological event with high mortality.
  • Statins, primarily cholesterol-lowering drugs, possess potential neuroprotective and anti-inflammatory properties.
  • The impact of continued statin use following acute ICH requires further investigation.

Purpose of the Study:

  • To evaluate the association between continued statin use and outcomes in patients with acute intracerebral hemorrhage.
  • To assess the effect of statins on mortality, neurological status, and inflammatory markers post-ICH.

Main Methods:

  • Retrospective cohort study of 178 patients with acute ICH.
  • Comparison of outcomes between 29 patients with continued statin use and 149 non-users.
  • Outcomes included inpatient mortality, NIHSS, GOS, and mortality at 10 days, 3 months, and 6 months.
  • Analysis of C-reactive protein (CRP), white blood cell (WBC) counts, and hepatic enzymes.

Main Results:

  • No mortality was observed in the statin group versus 12.7% in the non-user group by discharge (p=0.04).
  • Statin use was associated with significantly lower 6-month mortality (OR=0.32, p=0.04) and a trend towards NIHSS reduction.
  • Changes in WBC counts and CRP levels were associated with statin use, suggesting an immunomodulatory effect.

Conclusions:

  • Continued statin therapy after acute ICH may be associated with improved neurological function and reduced 6-month mortality.
  • The immunomodulatory effects of statins might contribute to their neuroprotective role in ICH.
  • Further prospective studies are warranted to confirm these findings.

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