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β2-Adrenergic receptor solutions for structural biology analyzed with microscale NMR diffusion measurements
Reto Horst1, Pawel Stanczak, Raymond C Stevens
1Department of Molecular Biology, The Scripps Research Institute, La Jolla, CA 92037, USA.
Angewandte Chemie (International Ed. in English)
|October 26, 2012
Abstract:
Microcoil NMR measurements were performed to determine the final composition of solutions of the β(2)-adrenergic receptor (β(2)AR) reconstituted with a detergent and to study the hydrodynamic properties of the detergent micelles containing β(2)AR. Standards are established for the reproducible preparation of G-protein-coupled receptor solutions for crystallization trials and solution NMR studies.
