Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cardiomyopathy III: Hypertrophic Cardiomyopathy01:29

Cardiomyopathy III: Hypertrophic Cardiomyopathy

Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...
Heart Failure II: Pathophysiology01:29

Heart Failure II: Pathophysiology

Systolic Heart Failure and Compensatory MechanismsSystolic heart failure (also termed HFrEF, Heart Failure with Reduced Ejection Fraction) is the most prevalent type of heart filure. It results in a decreased volume of blood being pumped from the ventricle. The aortic arch and carotid sinuses have baroreceptors that detect reduced blood pressure, triggering the sympathetic nervous system (SNS) to release epinephrine and norepinephrine. Initially, this response aims to boost heart rate and...
Cardiomyopathy I: Introduction and Classification01:25

Cardiomyopathy I: Introduction and Classification

Cardiomyopathy, or CMP, is a group of diseases affecting the myocardial structure, impairing its ability to pump blood effectively. This condition can lead to arrhythmias, heart failure, or sudden cardiac death.Cardiomyopathies are classified into primary and secondary categories:Primary Cardiomyopathy refers to conditions involving only the heart muscle that are often idiopathic (of unknown cause) or genetic. They primarily affect the myocardium without the involvement of other systemic...
Pathophysiology of Heart Failure01:17

Pathophysiology of Heart Failure

Heart failure (HF) is a progressive syndrome involving ventricles that leads to inadequate cardiac output. It can be classified based on location and output or ejection fraction. Ejection fraction (EF) is an essential measurement in the diagnosis and surveillance of HF. Reduced EF corresponds to systolic heart failure (HFrEF). However, HF with preserved ejection fraction (HFpEF) is becoming increasingly prevalent. Also known as diastolic HF, this form of HF is related to aging. The...
Cardiomyopathy V: Interprofessional Care01:29

Cardiomyopathy V: Interprofessional Care

Managing cardiomyopathy involves addressing underlying or precipitating causes, treating heart failure with medications, and implementing dietary changes and a balanced exercise and rest regimen.Lifestyle ModificationsCardiomyopathy patients should adopt a low-sodium diet to reduce fluid retention and manage heart failure. A personalized exercise and rest plan helps maintain physical fitness without overstraining the heart. Avoiding alcohol and tobacco is essential to prevent further damage to...
Cardiomyopathy II: Dilated Cardiomyopathy01:30

Cardiomyopathy II: Dilated Cardiomyopathy

Dilated cardiomyopathy, or DCM, is a progressive myocardial disorder characterized by ventricular chamber dilation and contractile dysfunction.EtiologyVarious factors can cause DCM, including hypertension and heavy alcohol intake, which contribute to the weakening and enlargement of the heart muscle. Viral infections, such as Coxsackievirus B, adenoviruses, and influenza, can lead to DCM by causing inflammation and damage to heart tissue. Certain chemotherapeutic agents, including daunorubicin,...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Indications, protocols, and interpretation of cardiovascular imaging for the evaluation and management of athletes: a clinical consensus statement of the European Association of Preventive Cardiology (EAPC) and the European Association of Cardiovascular Imaging (EACVI) of the ESC: Part 1-Exercise imaging.

European journal of preventive cardiology·2026
Same author

Indications, protocols, and interpretation of cardiovascular imaging for the evaluation and management of athletes: a clinical consensus statement of the European Association of Preventive Cardiology (EAPC) and the European Association of Cardiovascular Imaging (EACVI) of the ESC: Part 1-Exercise imaging.

European heart journal. Cardiovascular Imaging·2026
Same author

Effects of eccentric cycling training on aerobic and functional capacity in patients with heart failure: A randomised controlled trial.

Journal of science and medicine in sport·2026
Same author

Absolute versus change in pulmonary vascular resistance in relation to European Society of Cardiology/European Respiratory Society risk change in pulmonary arterial hypertension.

JHLT open·2026
Same author

International practices and variability in right heart echocardiography: results from the RVNet(Work) international survey.

Echo research and practice·2026
Same author

Reporting changes in right ventricular systolic pressure: insights from Classification and Regression Tree (CART) analysis.

Echo research and practice·2026
Same journal

Do blood flow restriction exercises offer additional benefits when compared to conventional exercises in musculoskeletal rehabilitation? A systematic review and meta-analysis.

British journal of sports medicine·2026
Same journal

Prevalence of eating disorders and disordered eating in athletes: a systematic review and meta-analysis.

British journal of sports medicine·2026
Same journal

Enhancing mountain safety through personalised exercise prescription: the MOVE project (PhD Academy Award).

British journal of sports medicine·2026
Same journal

Effectiveness of office-based vergence/accommodative therapy with movement for accommodative dysfunction in concussion-related convergence insufficiency: a secondary analysis of the CONCUSS randomised clinical trial.

British journal of sports medicine·2026
Same journal

Infographic. Active commuting is linked to lower coronary atherosclerosis.

British journal of sports medicine·2026
Same journal

Optimising exercise prescription for cancer-related fatigue, lean mass, physical function and muscle strength in women with breast cancer: a systematic review with dose-response network meta-analysis.

British journal of sports medicine·2026
See all related articles

Related Experiment Video

Updated: May 17, 2026

Scanning Electron Microscopy of Macerated Tissue to Visualize the Extracellular Matrix
10:21

Scanning Electron Microscopy of Macerated Tissue to Visualize the Extracellular Matrix

Published on: June 14, 2016

Peripheral vascular structure and function in hypertrophic cardiomyopathy.

Nicola Jayne Rowley1, Daniel J Green, Keith George

  • 1Research Institute for Sport and Exercise Science, Liverpool John Moores University, Liverpool, UK.

British Journal of Sports Medicine
|October 26, 2012
PubMed
Summary
This summary is machine-generated.

Hypertrophic cardiomyopathy (HCM) patients and athletes show distinct peripheral arterial differences, aiding in distinguishing pathological cardiac enlargement from exercise adaptations. These vascular changes highlight potential diagnostic markers beyond cardiac imaging.

More Related Videos

An Approach to Study Shape-Dependent Transcriptomics at a Single Cell Level
06:02

An Approach to Study Shape-Dependent Transcriptomics at a Single Cell Level

Published on: November 2, 2020

Investigating the Pathogenesis of MYH7 Mutation Gly823Glu in Familial Hypertrophic Cardiomyopathy using a Mouse Model
03:45

Investigating the Pathogenesis of MYH7 Mutation Gly823Glu in Familial Hypertrophic Cardiomyopathy using a Mouse Model

Published on: August 8, 2022

Related Experiment Videos

Last Updated: May 17, 2026

Scanning Electron Microscopy of Macerated Tissue to Visualize the Extracellular Matrix
10:21

Scanning Electron Microscopy of Macerated Tissue to Visualize the Extracellular Matrix

Published on: June 14, 2016

An Approach to Study Shape-Dependent Transcriptomics at a Single Cell Level
06:02

An Approach to Study Shape-Dependent Transcriptomics at a Single Cell Level

Published on: November 2, 2020

Investigating the Pathogenesis of MYH7 Mutation Gly823Glu in Familial Hypertrophic Cardiomyopathy using a Mouse Model
03:45

Investigating the Pathogenesis of MYH7 Mutation Gly823Glu in Familial Hypertrophic Cardiomyopathy using a Mouse Model

Published on: August 8, 2022

Area of Science:

  • Cardiology
  • Vascular Biology
  • Sports Medicine

Background:

  • Hypertrophic cardiomyopathy (HCM) is a primary cause of sudden cardiac death in young athletes.
  • Differentiating physiological (athlete's heart) from pathological (HCM) cardiac remodeling is clinically challenging.
  • Peripheral vascular adaptations in HCM are poorly understood, despite known effects of training on vasculature.

Purpose of the Study:

  • To investigate peripheral vascular differences between HCM patients and athletes.
  • To determine if arterial structure and function vary between HCM, athletes, and controls.
  • To identify potential non-cardiac markers for differentiating HCM from exercise-induced cardiac changes.

Main Methods:

  • High-resolution ultrasound was used to measure carotid and brachial artery diameter and wall thickness.
  • Flow-mediated dilation (FMD) of brachial arteries was assessed.
  • Age-matched groups of HCM patients (n=18), competitive athletes (n=18), and controls (n=10) were studied.

Main Results:

  • Significant differences in carotid and brachial artery wall thickness were observed between athletes and HCM patients.
  • Athletes exhibited greater brachial artery peak blood flow response, indicating altered resistance artery remodeling compared to HCM patients.
  • No significant differences were found in brachial artery FMD% between the groups.

Conclusions:

  • Peripheral arterial structure differs between HCM patients and athletes, despite similar cardiac characteristics.
  • These vascular differences may stem from HCM pathology or a general effect of physical activity on arteries.
  • Further research is needed to explore artery function and structure in athletic individuals with HCM.