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Related Experiment Video

Updated: May 17, 2026

Site-Directed Immobilization of Bone Morphogenetic Protein 2 to Solid Surfaces by Click Chemistry
11:20

Site-Directed Immobilization of Bone Morphogenetic Protein 2 to Solid Surfaces by Click Chemistry

Published on: March 29, 2018

Bactericidal strontium-releasing injectable bone cements based on bioactive glasses.

Delia S Brauer1, Natalia Karpukhina, Gopal Kedia

  • 11Unit of Dental Physical Sciences, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, Mile End Road, London E1 4NS, UK. delia.brauer@uni-jena.de

Journal of the Royal Society, Interface
|October 26, 2012
PubMed
Summary

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New injectable bone cements release strontium to fight infections and boost bone growth in osteoporosis patients. This strontium-substituted bioactive glass offers a dual benefit for bone repair and infection prevention.

Area of Science:

  • Biomaterials Science
  • Orthopedic Surgery
  • Infectious Diseases

Background:

  • Implant-related infections and osteoporosis pose significant challenges in orthopedic procedures.
  • Strontium has demonstrated potential for both antimicrobial and bone-enhancing properties.

Purpose of the Study:

  • To develop and evaluate strontium-releasing injectable bone cements for treating osteoporosis-related fractures.
  • To assess the antimicrobial efficacy and bone-forming potential of these novel cements.

Main Methods:

  • A series of melt-derived bioactive glasses (BG) with varying strontium substitution levels were synthesized.
  • Injectable cements were formulated by mixing BG powder with poly(acrylic acid) and water.
  • Compressive strength, strontium release kinetics, and in vitro bactericidal effects against Staphylococcus aureus and Streptococcus faecalis were evaluated.

Related Experiment Videos

Last Updated: May 17, 2026

Site-Directed Immobilization of Bone Morphogenetic Protein 2 to Solid Surfaces by Click Chemistry
11:20

Site-Directed Immobilization of Bone Morphogenetic Protein 2 to Solid Surfaces by Click Chemistry

Published on: March 29, 2018

Main Results:

  • Injectable cements achieved compressive strengths up to 35 MPa.
  • Strontium release increased with higher strontium substitution in the BG composition.
  • Significant reduction in bacterial cell counts (up to three orders of magnitude) was observed over 6 days.

Conclusions:

  • Strontium-substituted bioactive glass cements exhibit promising antimicrobial activity and potential for bone enhancement.
  • These novel cements are suitable for applications like vertebroplasty and kyphoplasty in osteoporotic patients.
  • The study demonstrates a viable strategy for designing dual-action bone cements to combat infection and improve bone regeneration.