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Fetal loss rate after chorionic villus sampling and subsequent amniocentesis
H Brandenburg1, M G Jahoda, L Pijpers
1Department of Clinical Genetics, Academic Hospital Dijkzigt, Erasmus University, Rotterdam, The Netherlands.
American Journal of Medical Genetics
|February 1, 1990
Summary
This study on 82 patients found that undergoing both chorionic villus sampling (CVS) and amniocentesis did not significantly increase fetal loss risk compared to individual procedures.
Area of Science:
- Perinatal Medicine
- Maternal-Fetal Medicine
- Prenatal Diagnostics
Background:
- Chorionic villus sampling (CVS) and amniocentesis are common prenatal diagnostic procedures.
- Assessing the combined risk of sequential CVS and amniocentesis is crucial for patient counseling.
- Previous data on combined procedures is limited.
Purpose of the Study:
- To evaluate the fetal loss rate in pregnancies undergoing both CVS and amniocentesis.
- To compare the combined procedure risk with the risks of each procedure performed individually.
Main Methods:
- Retrospective review of 82 patients.
- Procedures performed between May 1984 and May 1988.
- Analysis of fetal loss rates for combined CVS and amniocentesis versus separate procedures.
Main Results:
- A documented fetal loss rate of 2.5% for patients undergoing both procedures.
- This rate was not statistically different from the combined individual risks (CVS 1.9%; amniocentesis 1.0%).
Conclusions:
- Performing both chorionic villus sampling and amniocentesis sequentially in the same pregnancy does not appear to significantly elevate the overall fetal loss risk.
- Findings support the safety of combined procedures when indicated, based on historical data.