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Voltage-Dependent Potassium Current Recording on H9c2 Cardiomyocytes via the Whole-Cell Patch-Clamp Technique

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Digoxin intoxication: An old enemy in modern era.

Bahadir Kirilmaz¹, Serkan Saygi, Hasan Gungor

¹Department of Cardiology, Canakkale Onsekiz Mart University, Medical Faculty, Canakkale 17100, Turkey.

Journal of Geriatric Cardiology : JGC

|October 26, 2012

Summary

Digoxin intoxication remains a concern, especially in elderly females. Gastrointestinal complaints are the most frequent symptom, and mortality rates have decreased.

Keywords:

Arrhythmia Digitalis Digoxin intoxication Heart failure

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Area of Science:

Cardiology
Clinical Toxicology

Background:

Digoxin, despite newer treatments, still poses an intoxication risk.
Digoxin intoxication can be subtle and easily missed in clinical practice.

Purpose of the Study:

To analyze a case series of digoxin intoxication in the modern era.
To identify demographic, clinical, and laboratory characteristics of patients with digoxin intoxication.

Main Methods:

Retrospective analysis of 71 patients hospitalized with confirmed digoxin intoxication (serum digoxin > 2.0 ng/mL).
Data collected included demographics, digoxin use, comorbidities, concurrent medications, and ECG findings.

Main Results:

Over half of patients (53.5%) experienced heart failure symptoms.
The majority of patients (64%) were over 75 years old, and 67% were female.
Females showed higher rates of atrial fibrillation, hypertension, and gastrointestinal complaints.

Conclusions:

Mortality rates for digoxin intoxication have decreased.
Gastrointestinal complaints are the most prevalent symptom in digoxin intoxication cases.