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Related Concept Videos

Fibronectins Connect Cells with ECM01:25

Fibronectins Connect Cells with ECM

Fibronectin is an adhesive glycoprotein present in the extracellular matrix of embryogenic and adult tissue. These molecules primarily aid in regulating cell motility and attachment. A fibronectin molecule is composed of two identical polypeptide chains attached to each other by a pair of disulfide bonds at the C-terminal.
Both proteoglycans and collagen are attached to fibronectin proteins, which, in turn, are attached to integrin proteins. These integrin proteins interact with transmembrane...
Fibrous Proteins00:55

Fibrous Proteins

Fibrous proteins are either long and narrow proteins or assemble to form long and thin structures. They contain repetitive units and usually consist of either alpha helices or beta sheets and, in rare cases, a mix of both. The amino acids in the primary structure often consist of repeating amino acid sequences. The role of fibrous proteins is primarily structural. Many are located in the extracellular matrix and are present in connective tissues to impart strength and joint mobility. They are...
Fibril-associated Collagen01:11

Fibril-associated Collagen

Fibril-associated collagens are a type of collagens present in the extracellular matrix with interrupted triple helices or FACIT (Fibril-associated collagens interrupted triple-helices). FACIT help connect and attach the collagen fibrils with each other as well as with other proteins of the extracellular matrix.
For example, the type II collagen fibrils in cartilage have covalently bound type IX fibril-associated collagens at regular intervals. Other types of fibril-associated collagens are...
Type IV Collagen of Basal Lamina01:05

Type IV Collagen of Basal Lamina

Type IV collagen is a 400 nm long, network-forming collagen that acts as a barrier between the epithelial and endothelial cells. Type IV collagen  forms the backbone of the basement membrane by scaffolding with laminin, entactin, proteoglycans, and fibronectin. Apart from rendering structural support to the basement membrane, it also helps entail signaling potentials necessary for both pathological and physiological functions.
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Types of Intermediate Filaments01:31

Types of Intermediate Filaments

The intermediate filaments are an essential component of the cytoskeleton. Presently six types of intermediate filament have been identified. Type I and II are acidic and basic keratin proteins. Type III is of mesodermal origin and comprises four proteins: vimentin, desmin, glial fibrillary acidic protein (GFAP), and peripherin. Vimentin is commonly found in mesenchymal cells, desmin in muscle cells, GFAP in astrocytes, while peripherin is found in peripheral nervous system neurons (PNS). Type...
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The Structure of Intermediate Filaments

The intermediate filaments are one of three widely studied cytoskeletal filaments. They are so named as their diameter (10 nm) is in between that of microfilaments (7 nm) and the microtubules (25 nm).  These filaments are highly stable and can remain intact when exposed to high salt concentrations and detergents. These filaments are responsible for providing stability and mechanical support to the cells. They also help in cell adhesion and maintaining tissue integrity.
Intermediate filaments...

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Related Experiment Video

Updated: May 17, 2026

ECM Protein Nanofibers and Nanostructures Engineered Using Surface-initiated Assembly
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Multifunctional, supramolecular, continuous artificial nacre fibres.

Xiaozhen Hu1, Zhen Xu, Chao Gao

  • 1MOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University, 38 Zheda Road, Hangzhou 310027, P. R. China.

Scientific Reports
|October 26, 2012
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Summary

Scientists developed continuous nacre-mimetic fibers using graphene and hyperbranched polyglycerol (HPG). These scalable bio-inspired materials exhibit superior mechanical, electrical, and corrosion-resistant properties compared to natural nacre.

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Area of Science:

  • Materials Science
  • Biomimetics
  • Nanotechnology

Background:

  • Nature's materials, like nacre, offer exceptional properties due to their hierarchical structures.
  • Nacre's "brick-and-mortar" (B&M) structure, composed of aragonite platelets and biomacromolecules, provides strength, stiffness, and toughness.
  • Current nacre-mimetic composites are limited to small films, hindering large-scale applications.

Purpose of the Study:

  • To develop a scalable method for producing continuous nacre-mimetic fibers.
  • To create bio-inspired materials with enhanced structural integrity and functional properties.
  • To overcome the limitations of finite-sized nacre-mimetic films.

Main Methods:

  • Utilized wet-spinning assembly technology for fiber fabrication.
  • Incorporated alternating layers of graphene sheets and hyperbranched polyglycerol (HPG) binders.
  • Mimicked the natural "brick-and-mortar" (B&M) layered structure.

Main Results:

  • Successfully produced continuous macroscopic supramolecular fibers with a B&M architecture.
  • Achieved mechanical properties comparable or superior to nacre and bone.
  • Demonstrated excellent electrical conductivity and outstanding corrosion resistance.

Conclusions:

  • The developed wet-spinning strategy offers a scalable route to continuous nacre-mimetic fibers.
  • These bio-inspired fibers possess remarkable mechanical and functional properties.
  • The findings pave the way for advanced materials with applications in various fields.