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Neuroblastoma in a child with Wiedemann-Beckwith syndrome
D Chitayat1, J M Friedman, J E Dimmick
1Department of Medical Genetics, University Hospital Shaughnessy Site, University of British Columbia, Vancouver, Canada.
American Journal of Medical Genetics
|March 1, 1990
Abstract:
We report on a patient with Wiedemann-Beckwith syndrome (WBS) who developed abdominal neuroblastoma. Although WBS patients are known to have a higher incidence of embryonal tumors, this is only the 4th known case of neuroblastoma associated with this syndrome. Chromosomes on peripheral lymphocytes and tumor cells were normal. Children with WBS should be screened for a variety of embryonal neoplasms, not only Wilms tumor.