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Core-binding factor β increases the affinity between human Cullin 5 and HIV-1 Vif within an E3 ligase complex

Jason D Salter1, Geoffrey M Lippa, Ivan A Belashov

  • 1Department of Biochemistry and Biophysics, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, United States.

Biochemistry
|October 27, 2012
PubMed
Summary

The HIV-1 Vif protein binds tightly to cellular proteins, including Cullin 5 (Cul5) and core-binding factor β (CBFβ), to degrade the antiviral APOBEC3G (A3G). This interaction is crucial for viral replication and offers potential therapeutic targets.

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