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Allergic colitis in monozygotic preterm twins

Maria Elisabetta Baldassarre1, Annarita Cappiello, Nicola Laforgia

  • 1Department of Gynecology, Obstetrics and Neonatology-Section of Neonatology and NICU, University of Bari, Bari, Italy. mariellabaldassarre@gmail.com

Immunopharmacology and Immunotoxicology
|October 27, 2012
PubMed

Insights

Allergic colitis in infants, marked by rectal bleeding, can be resolved with a cow's milk protein-free diet (CMPFD). This case in twins suggests potential genetic or environmental factors influencing immune tolerance to cow's milk protein.

Area of Science:

  • Pediatrics
  • Immunology
  • Gastroenterology

Background:

  • Allergic colitis (AC) is a common condition in infants, presenting with rectal bleeding.
  • It typically occurs within the first few months of life in otherwise healthy infants.

Observation:

  • A case study involving monozygotic preterm twins presenting with rectal bleeding is described.
  • The symptoms in both twins were successfully resolved after implementing a cow's milk protein-free diet (CMPFD).

Findings:

  • The resolution of allergic colitis (AC) symptoms with a CMPFD in monozygotic twins suggests a strong link to cow's milk protein intolerance.
  • The occurrence in twins raises questions about the potential genetic or environmental influences on immune dysregulation and tolerance development.

Implications:

  • This case highlights the efficacy of a CMPFD in managing infant allergic colitis.
  • Further research into the genetic and environmental factors contributing to cow's milk protein allergy and immune tolerance is warranted.
  • The potential role of probiotics, such as Lactobacillus GG (LGG), in managing AC warrants further investigation.

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