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Insulin-dependent diabetes mellitus associated with danazol
D B Seifer1, L N Freedman, J R Cavender
1Department of Obstetrics and Gynecology, State University of New York Health Science Center, Syracuse.
American Journal of Obstetrics and Gynecology
|February 1, 1990
Summary
A young woman developed insulin-dependent diabetes mellitus after starting danazol for endometriosis. The diabetes resolved after discontinuing danazol, suggesting a potential drug-induced effect.
Area of Science:
- Endocrinology
- Reproductive Medicine
- Pharmacology
Background:
- Pelvic endometriosis is a common gynecological condition requiring medical management.
- Danazol is a synthetic steroid used to treat endometriosis.
- Endocrine and metabolic side effects of danazol are known but rare.
Observation:
- A case of a young woman with pelvic endometriosis is presented.
- Insulin-dependent diabetes mellitus (IDDM) emerged 8 weeks after initiating danazol therapy.
- The patient had no prior history of diabetes mellitus.
Findings:
- The onset of IDDM was temporally associated with danazol treatment.
- Discontinuation of danazol led to complete resolution of the diabetes.
- This suggests a potential causal link between danazol and new-onset diabetes.
Implications:
- This case highlights a previously unreported adverse effect of danazol.
- Clinicians should monitor for glucose metabolism changes in patients on danazol.
- Further investigation into danazol's diabetogenic potential is warranted.