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Update of research on drug resistance in small cell lung cancer chemotherapy
Yi-Tian Chen1, Bing Feng, Long-Bang Chen
1Department of Medical Oncology, Jinling Hospital, Nanjing, China.
Abstract:
Small cell lung cancer (SCLC) is characterized by a short cell doubling time, rapid progression and early occurrence of blood-borne and lymph metastasis. The malignancy is the highest of all lung cancer types. Although SCLC has a relatively good initial response to chemotherapy as well as radiotherapy, relapse or disease progression may occur quickly after the initial treatment. Drug resistance, especially multi-drug resistance, is the most important cause of failure of SCLC chemotherapy. This article provides a brief update of research on mechanisms of drug resistance in SCLC and reversal strategies.
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