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Updated: May 17, 2026
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Multi-Gene Single Nucleotide Polymorphism Detection in Gastric Cancer Based on Ion Semiconductor Sequencing Platform
Published on: May 10, 2024
Association between the GSTP1 codon 105 polymorphism and gastric cancer risk: an updated meta-analysis
Li-Dao Bao1, Jian-Xiang Niu, Hui Song
1Department of Pharmacy, Affiliated Hospital of Inner Mongolia Medical University, Hohhot City, China.
Asian Pacific Journal of Cancer Prevention : APJCP
|October 27, 2012
Summary
The glutathione S-transferase P1 (GSTP1) codon 105 polymorphism is linked to increased gastric cancer risk in Asians. However, no significant association was found in Caucasians, with some evidence suggesting a reduced risk in heterozygotes.
Area of Science:
- Genetics and Epidemiology
- Cancer Research
- Molecular Biology
Background:
- Gastric cancer (GC) is a significant global health concern.
- The role of genetic polymorphisms, such as glutathione S-transferase P1 (GSTP1) codon 105, in GC susceptibility is debated.
- Conflicting results exist regarding the association between GSTP1 polymorphism and GC risk.
Purpose of the Study:
- To provide a more accurate estimation of the association between GSTP1 codon 105 polymorphism and gastric cancer risk.
- To resolve conflicting findings from previous studies.
- To investigate potential ethnic and clinical variations in this association.
Main Methods:
- A comprehensive meta-analysis of relevant published studies was conducted.
- Fixed or random effect models were employed based on heterogeneity testing.
- Publication bias was assessed using Begg's funnel plots and Egger's regression test.
Main Results:
- The meta-analysis included 20 studies with 2,821 GC cases and 6,240 controls.
- No significant overall association between GSTP1 polymorphism and GC risk was observed globally.
- Significant associations were found in Asians (increased risk) and Caucasians (reduced risk for heterozygotes).
- GSTP1 polymorphism was associated with GC in patients with H. pylori infection and cardiac GC.
Conclusions:
- The GSTP1 codon 105 polymorphism may be associated with an increased risk of gastric cancer in Asian populations.
- GSTP1 heterozygote genotype might be linked to a reduced risk of gastric cancer.
- Further research is recommended to confirm these findings and address potential confounders.
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