[Vascular effects of perindopril arginine and indapamide fixed combination in patients with arterial hypertension]

Area of Science:

• Cardiovascular Medicine
• Pharmacology
• Hypertension Research

Context:

• Arterial hypertension (AH) poses significant cardiovascular risks.
• Assessing the impact of antihypertensive therapies on vascular function is crucial.
• Perindopril arginine and indapamide are commonly used in hypertension management.

Purpose:

• To evaluate the effects of a fixed-dose combination of perindopril arginine and indapamide on arterial stiffness and endothelial function in patients with AH.
• To assess changes in central aortic blood pressure, pulse wave velocity, and endothelium-dependent vasodilatation.

Summary:

• A 24-week study involving 27 AH patients showed perindopril arginine/indapamide significantly reduced central aortic systolic blood pressure by 10.7 mmHg and augmentation pressure by 3.6 mmHg.
• The combination therapy led to a decrease in carotid-radial pulse wave velocity (0.8 m/s) and improved endothelium-dependent vasodilatation by week 12.
• Office and ambulatory blood pressure decreased, with 74.1% of patients achieving target blood pressure (<140/90 mmHg) without an increase in orthostatic hypotension.

Impact:

• The fixed combination therapy demonstrates a beneficial effect on vascular parameters in hypertensive individuals.
• This regimen improves vascular function by reducing wave reflection, peripheral arterial stiffness, and enhancing endothelial function.
• Results suggest perindopril arginine/indapamide is an effective treatment option for managing hypertension and its vascular complications.