[Effect of nicotine and tar present in cigarette smoke on the process of atherogenesis]

Tobacco smoking is a major risk factor of the development of atherosclerosis and thrombosis. Components of tobacco smoke induce changes in the function of thrombocytes, endothelium, macrophages and smooth muscle cells of blood vessels. Smoking causes changes in activity of enzymes of antioxidant system by inducing production of reactive oxygen species. Alterations of cell function and enzyme activity may accelerate formation of atherosclerotic plaques. The compounds of tobacco smoke also promote atherogenesis by affecting gene expression. Aim of the present article is to review published data about molecular mechanisms underlying harmful effects of ingredients of tobacco smoke such as nicotine and tar on the progression of atherosclerosis.