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Related Experiment Videos

Listeria monocytogenes keratitis.

G W Zaidman1, P Coudron, J Piros

  • 1Department of Ophthalmology, Westchester County Medical Center, New York Medical College, Valhalla 10595.

American Journal of Ophthalmology
|March 15, 1990
PubMed
Summary

Listeria monocytogenes can cause severe bacterial keratitis. Aggressive treatment with both penicillin and gentamicin is crucial to prevent vision loss from this virulent corneal pathogen.

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Area of Science:

  • Ophthalmology
  • Microbiology
  • Infectious Diseases

Background:

  • Listeria monocytogenes is a bacterium that can cause serious infections.
  • Bacterial keratitis, an infection of the cornea, can lead to vision impairment.

Observation:

  • A farmer developed Listeria monocytogenes bacterial keratitis unresponsive to topical antibiotics.
  • A rabbit model was developed to study the pathogenesis of Listeria keratitis.
  • Infection severity in rabbits was dose-dependent, mimicking human symptoms at high inoculums.

Findings:

  • Combined topical and systemic penicillin and gentamicin effectively treated Listeria keratitis.
  • Monotherapy with penicillin or gentamicin was less effective than combination therapy.
  • Combination therapy led to rapid infection resolution and prevented corneal scarring.

Implications:

  • Listeria monocytogenes is a virulent corneal pathogen requiring prompt and aggressive treatment.
  • Combined penicillin and gentamicin therapy is recommended for Listeria keratitis.
  • Early and effective treatment can prevent permanent visual loss from Listeria infections.

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