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Related Concept Videos

Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
Cancer Therapies02:49

Cancer Therapies

Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
Cancer Therapies02:49

Cancer Therapies

Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...

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Potentiation of Anticancer Antibody Efficacy by Antineoplastic Drugs: Detection of Antibody-drug Synergism Using the Combination Index Equation
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Combination therapies.

M Oudega1, E J Bradbury, M S Ramer

  • 1Departments of Physical Medicine and Rehabilitation, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA. moudega@pitt.edu

Handbook of Clinical Neurology
|October 27, 2012
PubMed
Summary
This summary is machine-generated.

Developing effective spinal cord injury (SCI) treatments requires careful selection and sequencing of therapies. Combination therapies aim to address molecular imbalances and functional impairments for better repair outcomes.

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Area of Science:

  • Neuroscience
  • Regenerative Medicine
  • Biomedical Engineering

Background:

  • Spinal cord injury (SCI) leads to molecular imbalances, glial scar formation, and functional deficits.
  • Current treatments are limited, necessitating novel therapeutic strategies.
  • Repairing the spinal cord likely requires a multifaceted approach.

Purpose of the Study:

  • To review single treatments for spinal cord injury (SCI) and their diverse effects.
  • To analyze the potential and challenges of combination therapies for SCI.
  • To discuss considerations for designing and implementing effective SCI combination therapies.

Main Methods:

  • Discussion of single treatment strategies, including growth/survival promotion (neurotrophins, cyclic AMP) and inhibition reduction (antimyelin-associated inhibitors, glial scar digestion).
  • Overview of preclinical combination therapy studies in animal models.
  • Analysis of critical factors for combination therapy design: timing, nature of treatments, and delivery methods.

Main Results:

  • Single treatments possess multiple actions, some potentially synergistic or antagonistic within a combination.
  • Preclinical studies show variable success rates for different combination therapy approaches.
  • Careful consideration of treatment interactions and delivery is crucial for efficacy.

Conclusions:

  • A combination therapy approach is promising for spinal cord injury (SCI) repair.
  • Optimizing combination therapies requires understanding individual treatment effects and interactions.
  • Strategic design, considering timing, delivery, and chronic injury, is essential for clinical translation.