Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Assessment of Diffusion and Perfusion01:17

Assessment of Diffusion and Perfusion

Understanding and evaluating diffusion and perfusion is critical in assessing a patient's respiratory and circulatory health. These processes play key roles in maintaining the body's internal environment, ensuring that tissues receive adequate oxygen while waste products are efficiently removed.
The Role of Diffusion in Respiration
Diffusion is the process by which molecules move from an area of higher concentration to an area of lower concentration. In the respiratory system, this principle...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Skin pigmentation bias in regional brain oximetry measurements?

Critical care (London, England)·2023
Same author

Implications on hypnotherapy: Neuroplasticity, epigenetics and pain.

Neuroscience and biobehavioral reviews·2021
Same author

Influence of study design on effects of mask wearing on fMRI BOLD contrast and systemic physiology - A comment on Law et al. (2021).

NeuroImage·2021
Same author

Fluctuations in measured radioactive decay rates inside a modified Faraday cage: Correlations with space weather.

Scientific reports·2020
Same author

Impact of Skull Thickness on Cerebral NIRS Oximetry in Neonates: An in silico Study.

Advances in experimental medicine and biology·2020
Same author

Reducing False Alarm Rates in Neonatal Intensive Care: A New Machine Learning Approach.

Advances in experimental medicine and biology·2020

Related Experiment Video

Updated: May 17, 2026

MRI Mapping of Cerebrovascular Reactivity via Gas Inhalation Challenges
09:33

MRI Mapping of Cerebrovascular Reactivity via Gas Inhalation Challenges

Published on: December 17, 2014

End-tidal CO2: an important parameter for a correct interpretation in functional brain studies using speech tasks.

F Scholkmann1, U Gerber2, M Wolf3

  • 1Institute of Complementary Medicine KIKOM, University of Bern, 3010 Bern, Switzerland; Biomedical Optics Research Laboratory, Division of Neonatology, University Hospital Zurich, 8091 Zurich, Switzerland.

Neuroimage
|October 27, 2012
PubMed
Summary
This summary is machine-generated.

Speech tasks like recitation decrease end-tidal CO2 (PETCO2), leading to changes in cerebral blood flow and oxygenation. Monitoring PETCO2 is crucial for accurate interpretation of brain activity during speech studies.

Keywords:
End-tidal CO(2)Functional near-infrared spectroscopyP(ET)CO(2)PaCO(2)Partial pressure of carbon dioxide in the arterial bloodPartial pressure of end-tidal carbon dioxideSpeech studiesfNIRS

More Related Videos

Expired CO2 Measurement in Intubated or Spontaneously Breathing Patients from the Emergency Department
07:52

Expired CO2 Measurement in Intubated or Spontaneously Breathing Patients from the Emergency Department

Published on: January 29, 2011

Related Experiment Videos

Last Updated: May 17, 2026

MRI Mapping of Cerebrovascular Reactivity via Gas Inhalation Challenges
09:33

MRI Mapping of Cerebrovascular Reactivity via Gas Inhalation Challenges

Published on: December 17, 2014

Expired CO2 Measurement in Intubated or Spontaneously Breathing Patients from the Emergency Department
07:52

Expired CO2 Measurement in Intubated or Spontaneously Breathing Patients from the Emergency Department

Published on: January 29, 2011

Area of Science:

  • Neuroscience
  • Physiology
  • Speech Science

Background:

  • Carbon dioxide levels significantly influence cerebral blood flow.
  • Speech production alters breathing patterns, potentially affecting blood CO2.
  • Understanding these effects is vital for neuroimaging studies involving speech.

Purpose of the Study:

  • To investigate the impact of different speech tasks on end-tidal CO2 (PETCO2), cerebral hemodynamics, and oxygenation.
  • To compare the effects of prose recitation, alliteration, hexameter recitation, and mental arithmetic on brain activity.
  • To determine the relationship between breathing changes during speech and cerebral responses.

Main Methods:

  • 24 healthy adults performed four tasks: prose recitation (PR), alliteration (AR), hexameter (HR), and mental arithmetic (MA).
  • Measurements included PETCO2, tissue oxygen saturation (StO2), and hemoglobin concentrations ([O2Hb], [HHb], [tHb]) using fNIRS.
  • Statistical analysis compared task performance to baseline, examining effects on the prefrontal cortex (PFC) of both hemispheres.

Main Results:

  • All tasks significantly decreased PETCO2, with mental arithmetic showing the smallest reduction.
  • Recitation tasks (PR, AR, HR) led to decreased StO2 and [O2Hb] in the PFC, with specific laterality observed.
  • [HHb] increased during AR, while [tHb] decreased during HR and other recitation tasks, indicating altered cerebral hemodynamics.

Conclusions:

  • Task-induced hyperventilation causes hypocapnia, primarily driving the observed changes in cerebral hemodynamics and oxygenation.
  • Speech tasks significantly impact cerebral oxygenation and blood flow, mediated by changes in CO2 levels.
  • PETCO2 monitoring is recommended during neuroimaging studies of speech to ensure accurate interpretation of fNIRS and fMRI data.