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Vitamin E supplementation and lifespan in model organisms.

I M A Ernst¹, K Pallauf, J K Bendall

¹Institute of Human Nutrition and Food Science, Christian-Albrechts-University Kiel, Germany. ernst@foodsci.uni-kiel.de

Ageing Research Reviews

|October 27, 2012

Summary

Vitamin E supplementation does not consistently extend lifespan in model organisms. Research indicates varied effects, including decreased longevity, suggesting no universal benefit for vitamin E in promoting longer life.

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Area of Science:

Gerontology and Aging Research
Nutritional Science and Metabolism

Background:

Vitamin E, a group of fat-soluble compounds including tocopherols and tocotrienols, is known for its antioxidant properties.
Previous research has explored the potential of vitamin E to influence aging processes and lifespan across various species.

Purpose of the Study:

To conduct a comprehensive literature review on the effects of vitamin E on lifespan in diverse model organisms.
To synthesize findings from studies investigating tocopherols and tocotrienols in relation to longevity.

Main Methods:

Systematic literature search of PubMed and ISI Web of Knowledge databases up to 2011.
Inclusion of studies using keywords: "tocopherols", "tocotrienols", "lifespan", and "longevity".
Analysis of 24 studies involving model organisms: single-cell organisms, rotifers, Caenorhabditis elegans, Drosophila melanogaster, and laboratory rodents.

Main Results:

The literature review revealed inconsistent effects of vitamin E on lifespan.
Some studies reported increased lifespan, while others found no significant changes or even a decrease in lifespan with vitamin E supplementation.
Variability in outcomes may be attributed to species-specific responses, differing vitamin E concentrations, and specific congeners used.

Conclusions:

There is no consistent evidence supporting a beneficial effect of vitamin E on lifespan in model organisms.
These findings align with observations from human intervention studies regarding vitamin E and longevity.
Further research is needed to understand the complex interactions between vitamin E, aging, and lifespan across different biological systems.