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Related Experiment Video

Updated: May 17, 2026

Co-analysis of Brain Structure and Function using fMRI and Diffusion-weighted Imaging
17:06

Co-analysis of Brain Structure and Function using fMRI and Diffusion-weighted Imaging

Published on: November 8, 2012

Layer-specific intracortical connectivity revealed with diffusion MRI.

Christoph W U Leuze1, Alfred Anwander, Pierre-Louis Bazin

  • 1Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany.

Cerebral Cortex (New York, N.Y. : 1991)
|October 27, 2012
PubMed
Summary
This summary is machine-generated.

We discovered that tangential diffusion is orientationally coherent on the human cortical surface. Diffusion magnetic resonance imaging (dMRI) successfully tracked these intracortical fiber pathways, offering new insights into brain organization.

Keywords:
Stria of Gennaricrossing-fiber tractographydiffusion tensor imaginglayer 1visual cortex

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Last Updated: May 17, 2026

Co-analysis of Brain Structure and Function using fMRI and Diffusion-weighted Imaging
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Published on: November 8, 2012

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Area of Science:

  • Neuroimaging
  • Human Brain Anatomy

Background:

  • Histological methods offer limited 3D organization insights in the human brain.
  • Diffusion magnetic resonance imaging (dMRI) provides advanced understanding of brain structure.

Purpose of the Study:

  • To investigate the orientation of tangential diffusion at the human cortical surface.
  • To track intracortical fiber pathways using dMRI.

Main Methods:

  • Utilized high-resolution diffusion magnetic resonance imaging (dMRI) on a postmortem human brain block.
  • Analyzed fiber orientation within four distinct cortical laminae.

Main Results:

  • Demonstrated orientationally coherent tangential diffusion at the human cortical surface.
  • Identified distinct diffusion patterns (radial and tangential) across cortical laminae.
  • Distinguished tangential diffusion at the surface, radial diffusion below, mixed diffusion at the Stria of Gennari, and radial diffusion deep within the cortex.

Conclusions:

  • Tangential diffusion is orientationally coherent at the human cortical surface.
  • dMRI reveals layer-dependent fiber orientation, surpassing histological limitations.
  • Intracortical fiber pathways can be tracked non-invasively.