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X-Ray Crystallography to Study the Oligomeric State Transition of the Thermotoga maritima M42 Aminopeptidase TmPep1050
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Pitfalls in the interpretation of structural changes in mutant proteins from crystal structures

P R Pokkuluri1, X Yang, Y Y Londer

  • 1Biosciences Division, Argonne National Laboratory, Lemont, IL 60439, USA.

Journal of Structural and Functional Genomics
|October 27, 2012
PubMed
Summary

Protein crystal packing, not mutation, caused distant structural changes in PpcA protein mutants. Careful analysis of crystal lattice is crucial to avoid misinterpreting structural data.

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