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[Nalbuphine as compared with pethidine for postoperative pain therapy]
G Mitterschiffthaler1, A Theiner, C Wieser
1Klinik für Anästhesie und Allgemeine Intensivmedizin, Universität Innsbruck, Osterreich.
Anasthesie, Intensivtherapie, Notfallmedizin
|January 1, 1990
Summary
Nalbuphine, an opioid analgesic, caused more sedation than meperidine but offered similar postoperative pain relief. While safe, its pronounced sedative effects require consideration in clinical use.
Area of Science:
- Anesthesiology
- Pharmacology
- Pain Management
Background:
- Opioid analgesics are crucial for postoperative pain management.
- Nalbuphine, a mixed agonistic-antagonistic opioid, presents potential advantages.
- Comparative efficacy and safety data are essential for clinical decision-making.
Purpose of the Study:
- To compare the efficacy and safety of nalbuphine versus meperidine for postoperative pain relief.
- To evaluate sedation levels and pain management quality after gynecological surgery.
Main Methods:
- A comparative study involving 100 patients receiving meperidine (1 mg/kg) and 70 patients receiving nalbuphine (0.3 mg/kg) intravenously.
- Standardized halothane anesthesia without intraoperative opioids was employed.
- Postoperative assessments included vigilance (sedation), pain relief quality, and duration at 0, 15, 30, and 60 minutes.
Main Results:
- Nalbuphine group exhibited significantly more pronounced sedation compared to the meperidine group.
- No significant differences were observed in the quality or duration of pain relief between the two groups.
- Six patients in the nalbuphine group experienced transient wake-up reactions due to receptor antagonism; 36 patients required reinjection within the first hour.
Conclusions:
- Nalbuphine is a safe opioid for postoperative pain management.
- The significant increase in sedation with nalbuphine necessitates careful clinical consideration.
- Further research may explore optimal dosing or patient selection to mitigate sedation.