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Related Experiment Video

Updated: May 17, 2026

Rapid In Situ Hybridization using Oligonucleotide Probes on Paraformaldehyde-prefixed Brain of Rats with Serotonin Syndrome

Rapid In Situ Hybridization using Oligonucleotide Probes on Paraformaldehyde-prefixed Brain of Rats with Serotonin Syndrome

Published on: September 23, 2015

Serotonin: from top to bottom.

Sara Fidalgo¹, Dobril K Ivanov, Shona H Wood

¹School of Pharmacy and Biomolecular Sciences, University of Brighton, Brighton, UK.

|October 27, 2012

Summary

This summary is machine-generated.

Serotonin, a key neurotransmitter, influences aging and disease. This review explores serotonin

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Thermostabilization, Expression, Purification, and Crystallization of the Human Serotonin Transporter Bound to S-citalopram

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Published on: November 27, 2016

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Rapid In Situ Hybridization using Oligonucleotide Probes on Paraformaldehyde-prefixed Brain of Rats with Serotonin Syndrome

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Published on: September 23, 2015

Thermostabilization, Expression, Purification, and Crystallization of the Human Serotonin Transporter Bound to S-citalopram

Thermostabilization, Expression, Purification, and Crystallization of the Human Serotonin Transporter Bound to S-citalopram

Published on: November 27, 2016

Area of Science:

Neuroscience and Aging Research
Molecular Biology and Disease Mechanisms

Background:

Serotonin (5-HT) is a conserved monoamine neurotransmitter vital for numerous physiological functions.
Age-related decline in serotonin systems is linked to diseases like diabetes and cardiovascular conditions.
Understanding serotonin's role in aging is crucial due to its impact on behavior and physiology.

Purpose of the Study:

To comprehensively analyze serotonin's distribution, function, and interactions across multiple organ systems.
To elucidate the link between serotonin function, aging, and the pathology of age-related diseases.
To explore microRNA regulation of serotonin and its therapeutic potential in aging.

Main Methods:

Literature review and comprehensive analysis of existing research on serotonin and aging.
Examination of serotonin's role in the brain, gastrointestinal, skeletal, vascular, and immune systems.
Discussion of microRNA regulation and potential pharmacological interventions.

Main Results:

Serotonin function is intricately linked to aging processes across various physiological systems.
Dysregulation of serotonin contributes to the pathology of age-related diseases.
MicroRNAs play a significant role in regulating serotonin, with implications for aging.

Conclusions:

Serotonin is implicated in whole-body aging through its systemic effects and interactions.
Targeting serotonin pathways, potentially modulated by microRNAs, offers therapeutic avenues for age-related diseases.
Further research is needed to fully understand and leverage these complex links.