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Updated: May 17, 2026

Characterization of Thymus-dependent and Thymus-independent Immunoglobulin Isotype Responses in Mice Using Enzyme-linked Immunosorbent Assay

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Itpr3 Is responsible for the mouse tufted (tf) locus.

Hillary T Ellis¹, Michael G Tordoff, M Rockwell Parker

¹Monell Chemical Senses Center, 3500 Market St., Philadelphia, PA 19104, USA.

The Journal of Heredity

|October 27, 2012

Summary

This summary is machine-generated.

Researchers identified the inositol triphosphate receptor type 3 (Itpr3) gene as responsible for the tufted (tf) hair loss and regrowth phenotype in BTBR mice. This finding clarifies the genetic basis of this classic mouse model.

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Area of Science:

Genetics
Developmental Biology
Mammalian Hair Follicle Development

Background:

The tufted (tf) locus in mice is known to cause a distinct hair loss and regrowth phenotype.
This phenotype is particularly notable in the BTBR mouse strain, serving as a classic model for studying hair cycle dynamics.

Purpose of the Study:

To genetically identify the specific gene underlying the tufted (tf) locus in mice.
To elucidate the molecular basis of the hair loss and regrowth phenotype observed in BTBR mice.

Main Methods:

Positional cloning techniques were employed to narrow down the genomic region containing the causative gene.
Complementation mapping was utilized to confirm the identity of the gene responsible for the tf phenotype.

Main Results:

The gene identified as responsible for the tf locus is Itpr3, which encodes the inositol triphosphate receptor type 3.
This identification provides a molecular target for understanding the tf phenotype.

Conclusions:

The inositol triphosphate receptor type 3 (Itpr3) is the gene responsible for the classic tufted (tf) hair loss and regrowth phenotype in BTBR mice.
This discovery advances the understanding of hair follicle development and regeneration genetics.