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Do vasospasms provoke ocular diseases?

P Gasser1, J Flammer, U Guthauser

  • 1Department of Internal Medicine, St. Claraspital, Basel, Switzerland.

Angiology
|March 1, 1990
PubMed
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Peripheral vasospasms, diagnosed via nailfold capillaroscopy, may contribute to low-tension glaucoma. This finding suggests a potential link between vascular issues and vision loss, even without high intraocular pressure.

Area of Science:

  • Ophthalmology
  • Vascular Medicine
  • Neurology

Background:

  • Peripheral vasospasms, often associated with conditions like Raynaud's disease, can manifest in various parts of the body.
  • Nailfold capillaroscopy is a diagnostic tool for assessing peripheral microvascular abnormalities.
  • Low-tension glaucoma is characterized by optic nerve damage and visual field loss without elevated intraocular pressure.

Purpose of the Study:

  • To investigate the potential role of peripheral vasospasms in the development of low-tension glaucoma.
  • To explore the relationship between ocular vasospasms and characteristic glaucoma-related visual field defects.

Main Methods:

  • Nailfold video-capillaroscopy was used to diagnose peripheral vasospasms in 16 patients with a history of cold extremities.

Related Experiment Videos

  • Patients underwent ophthalmological examinations, including visual field testing, to assess for glaucoma-like defects.
  • The effect of cold provocation (cooling one hand) and nifedipine treatment on ocular vasospasms and visual fields was evaluated.

    • Main Results:

    • Peripheral vasospasms were confirmed in patients presenting with low-tension glaucoma and visual field defects.
    • Visual field defects were prechiasmal, suggesting a vascular origin rather than a central nervous system issue.
    • Ocular vasospasms were aggravated by cold exposure and improved with nifedipine treatment.

    Conclusions:

    • Peripheral vasospasms may be a significant factor in the pathogenesis of low-tension glaucoma.
    • This study identifies a potential link between a general vasospastic syndrome and the development of glaucoma.
    • Findings suggest that vasospasm should be considered in the differential diagnosis of low-tension glaucoma.