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Sinonasal inflammation in COPD: a systematic review.

Kåre Håkansson¹, Lars Konge, Simon F Thomsen

¹Head & Neck Surgery and Audiology, Rigshospitalet and Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen.

The European Respiratory Journal

|October 27, 2012

Summary

Chronic obstructive pulmonary disease (COPD) patients often have sinonasal symptoms. Smoking, not systemic inflammation, appears to trigger this COPD-related sinonasal disease, though further research is needed.

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Area of Science:

Pulmonology
Otolaryngology
Respiratory Medicine

Background:

Patients with chronic obstructive pulmonary disease (COPD) frequently experience sinonasal symptoms.
Smoking is a known cause of nasal disease and may be implicated in COPD-related sinonasal conditions.
Nasal inflammation in COPD patients shares similarities with bronchial inflammation.

Purpose of the Study:

To review the evidence for COPD-related sinonasal disease.
To explore the potential triggers and characteristics of this condition.
To identify areas for future research in COPD and sinonasal health.

Main Methods:

Literature review of studies investigating sinonasal symptoms in COPD patients.
Analysis of evidence linking smoking to nasal disease.
Comparison of inflammatory patterns in the nose and bronchi of COPD patients.

Main Results:

A significant association exists between COPD and sinonasal symptoms.
Evidence suggests smoking, rather than systemic inflammation, is a primary trigger for COPD-related sinonasal disease.
Nasal inflammation in COPD patients mirrors that found in the bronchi.

Conclusions:

COPD-related sinonasal disease is a recognized condition.
Smoking is identified as a key etiological factor.
Further characterization of sinonasal symptoms and endoscopic findings in COPD is required, along with studies on quality of life impacts.