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Molecular events leading to the creation of a pandemic influenza virus

Shipra Sharma1, Adarsh Mayank, Sunil K Lal

  • 1P. O. Box. 10504, ICGEB, Aruna Asaf Ali Road, New Delhi, 110067 India.

Indian Journal of Microbiology
|October 27, 2012
PubMed

Insights

The 2009 H1N1/09 influenza A virus, a novel swine-origin strain, has caused a mild pandemic. Its molecular markers suggest low pathogenicity, but it may evolve into a more severe strain.

Area of Science:

  • Virology
  • Epidemiology
  • Public Health

Background:

  • Influenza A virus poses a significant threat, causing annual respiratory illness and potential pandemics.
  • The 2009 H1N1/09 pandemic involved a novel swine-origin influenza A virus that spread globally.
  • This virus originated from a mix of avian, human, and swine viral strains.

Purpose of the Study:

  • To review the molecular and antigenic determinants of the H1N1/09 influenza A virus.
  • To discuss the characteristics defining H1N1/09 as a low pathogenic strain.
  • To explore the potential for H1N1/09 to evolve into a more virulent form.

Main Methods:

  • Review of existing literature on H1N1/09 influenza A virus.
  • Analysis of molecular and antigenic data related to H1N1/09.
  • Assessment of pathogenicity and transmissibility markers.

Main Results:

  • The H1N1/09 pandemic has been relatively mild to date.
  • The virus lacks previously identified molecular markers for high pathogenicity and transmissibility.
  • The H1N1/09 strain is considered low pathogenic based on current data.

Conclusions:

  • The H1N1/09 influenza A virus exhibits low pathogenicity due to the absence of specific molecular markers.
  • Subsequent mutations and reassortments could potentially increase the pathogenicity and transmissibility of the H1N1/09 strain.
  • Continuous monitoring of H1N1/09 evolution is crucial for pandemic preparedness.
Keywords:
Antigenic determinantsH1N1PandemicPathogenicity

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