Related Experiment Video
Updated: May 17, 2026

05:59
Nasal Wipes for Influenza A Virus Detection and Isolation from Swine
Published on: December 4, 2015
Pandemic swine influenza virus (H1N1): A threatening evolution
Madhu Khanna1, Binod Kumar, Neha Gupta
1Department of Respiratory Virology, V. P. Chest Institute, University of Delhi, Delhi, India.
Indian Journal of Microbiology
|October 27, 2012
Summary
The 2009 H1N1 influenza A virus, a novel reassortment of human, avian, and swine strains, emerged due to genetic exchange in swine. Ongoing global efforts aim to combat this pandemic threat.
Area of Science:
- Virology
- Evolutionary Biology
- Epidemiology
Background:
- Microorganisms, including viruses, exhibit remarkable adaptability to changing environments.
- Influenza viruses are known for their ability to exchange genetic material between human and animal populations.
- The swine population serves as a critical reservoir for influenza virus reassortment events.
Purpose of the Study:
- To investigate the origin and evolutionary trajectory of the 2009 H1N1 influenza A virus.
- To analyze the factors contributing to its emergence as a pandemic threat.
- To discuss current pandemic scenarios and potential control measures.
Main Methods:
- Review of epidemiological data on influenza cases.
- Analysis of genetic reassortment events in influenza viruses.
- Examination of the role of swine populations in viral evolution.
Main Results:
- The 2009 H1N1 influenza A outbreak was caused by a novel reassortant virus.
- Swine populations were identified as key sites for the genetic reassortment leading to the 2009 H1N1 strain.
- The virus represents a significant evolutionary advancement with pandemic potential.
Conclusions:
- The emergence of the 2009 H1N1 influenza A virus highlights the dynamic evolution of influenza viruses.
- Understanding swine's role in viral reassortment is crucial for pandemic preparedness.
- Continued global health efforts are necessary to manage and combat influenza pandemics.
Related Concept Videos
Influenza
Influenza is an acute, highly communicable viral disease that affects the respiratory tract and is responsible for seasonal epidemics worldwide. Influenza A is the most prevalent type associated with widespread outbreaks and is subtyped based on two surface glycoproteins: hemagglutinin (H) and neuraminidase (N), as in H1N1. These glycoproteins are essential for viral infectivity, transmission, and immune recognition. Transmission occurs primarily through respiratory droplets and contaminated...
Infectious Diseases and Their Occurrence
Infectious diseases appear in populations through various transmission patterns, influenced by pathogen characteristics, population immunity, environmental conditions, and social behavior. Understanding these patterns is essential for effective public health surveillance and intervention. These categories—sporadic, outbreak, epidemic, pandemic, and endemic—help frame the nature and scope of disease events.Sporadic diseases occur irregularly and infrequently, without a predictable temporal or...
Viral Mutations
A mutation is a change in the sequence of bases of DNA or RNA in a genome. Some mutations occur during replication of the genome due to errors made by the polymerase enzymes that replicate DNA or RNA. Unlike DNA polymerase, RNA polymerase is prone to errors because it is not capable of “proofreading” its work. Viruses with RNA-based genomes, like HIV, therefore accrue mutations faster than viruses with DNA-based genomes. Because mutation and recombination provide the raw material for adaptive...
Viral Recombination
Cells are sometimes infected by more than one virus at once. When two viruses disassemble to expose their genomes for replication in the same cell, similar regions of their genomes can pair together and exchange sequences in a process called recombination. Alternatively, viruses with segmented genomes can swap segments in a process called reassortment.
Leaky Scanning
During most eukaryotic translation processes, the small 40S ribosome subunit scans an mRNA from its 5' end until it encounters the first start AUG codon. The large 60S ribosomal subunit then joins the smaller one to initiate protein synthesis. The location of the translation initiation is largely determined by the nucleotides near the start codon as there may be multiple translation initiation sites present on the mRNA. Marilyn Kozak discovered that the sequence RCCAUGG (where R stands for...
Evolution of Microbial Genome
Microbial genome evolution is a highly dynamic process shaped by continual gene gain and loss across species and strains. This genomic flexibility allows microorganisms to adapt rapidly to environmental pressures and interactions with other organisms. Central to understanding this diversity is the distinction between the core and pan genomes.The core genome comprises the genes shared by all sampled strains of a species, representing essential functions needed for fundamental cellular processes.

