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Updated: May 17, 2026

Methods to Increase the Sensitivity of High Resolution Melting Single Nucleotide Polymorphism Genotyping in Malaria
Published on: November 10, 2015
Strain variation and gene hunting in malaria
Y D Sharma1, J M Fakruddin, N Bhutani
1Department of Biotechnology, All India Institute of Medical Sciences, 110029 New Delhi, India.
Abstract:
Malaria still remains uncontrolled affecting millions and killing many. We have found the high chloroquine-resistance in Rajasthan epidemic which contains multipleP.falciparum strains. Large number of variantP.falciparum strains exist in India which should be taken into account for future malaria control strategies. We have characterised several parasite molecules which are involved in the hostparasite interaction. They can be used to develop the molecular therapy or antimalarial drugs for malaria. The parasite enzymes described by us will be quite useful in this regard, particularly in drug development.
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