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Flow Cytometry

Flow Cytometry

The development of flow cytometry techniques began in 1934 with initial attempts by Andrew Moldavan, a bacteriologist who counted the cells in a flowing capillary system. Moldavan pumped cells through a capillary tube focused under a microscope for visualization. The invention of photometry allowed the measurement of differentially-stained cells, and Louis Kamentsky developed the first multiparameter flow cytometer in 1965 to identify and count the cancer cells in cervical tissue specimens.
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Related Experiment Video

Updated: May 17, 2026

Flow Cytometry to Estimate Leukemia Stem Cells in Primary Acute Myeloid Leukemia and in Patient-derived-xenografts, at Diagnosis and Follow Up

Flow Cytometry to Estimate Leukemia Stem Cells in Primary Acute Myeloid Leukemia and in Patient-derived-xenografts, at Diagnosis and Follow Up

Published on: March 26, 2018

Flow cytometry in acute leukemia.

Renu Saxena¹, Hema Anand

¹Department of Hematology, All India Institute of Medical Sciences, New Delhi, India.

Indian Journal of Hematology & Blood Transfusion : an Official Journal of Indian Society of Hematology and Blood Transfusion

|October 27, 2012

Summary

This summary is machine-generated.

Flow cytometry immunophenotyping is crucial for diagnosing acute leukemia. This review covers recent advances in methods, quality control, and data analysis for accurate diagnosis.

Keywords:

Acute leukemia Flow cytometery Immunophenotyping Leukemia

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Area of Science:

Hematology
Clinical Pathology
Immunology

Background:

Flow cytometry immunophenotyping is a key diagnostic method for acute leukemia.
Accurate diagnosis relies on integrating flow cytometry with morphology and cytochemistry.

Purpose of the Study:

To review recent advancements in flow cytometry techniques for acute leukemia.
To discuss quality control, troubleshooting, and data analysis in flow cytometry for leukemia diagnosis.

Main Methods:

Literature review of recent advances in flow cytometry.
Focus on multiparameter flow cytometry applications in acute leukemia.

Main Results:

Multiparameter flow cytometry enhances diagnostic accuracy in acute leukemia.
Recent advances improve the reliability and efficiency of flow cytometry methods.

Conclusions:

Flow cytometry is an invaluable tool for acute leukemia diagnosis.
Continuous updates in methods and quality control are essential for optimal clinical application.