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Updated: May 17, 2026

Rapid Fractionation and Isolation of Whole Blood Components in Samples Obtained from a Community-based Setting
Published on: November 30, 2015
Rational use of blood components - an audit
Minal Wade1, Ratna Sharma, Mamta Manglani
1Division of Hematology Oncology, Department of Pediatrics, Lokmanya Tilak Municipal Medical College & General Hospital, Sion, Mumbai, 400 022 India.
This study found that 16.9% of blood component transfusions in pediatric and neonatal wards were inappropriate, with fresh frozen plasma being the most misused. Implementing transfusion guidelines can improve blood component utilization.
Area of Science:
- Pediatric Transfusion Medicine
- Hematology
- Clinical Audit
Background:
- Blood component therapy is crucial in pediatric and neonatal care.
- Ensuring appropriate use of blood products is essential for patient safety and resource management.
Purpose of the Study:
- To evaluate the appropriateness of blood component utilization in pediatric and neonatal intensive care units.
- To identify areas of suboptimal transfusion practices.
Main Methods:
- An observational study was conducted over six months in a tertiary care institute.
- Transfusion episodes in patients under 12 years of age across various pediatric subspecialties were assessed against predefined criteria.
Main Results:
- Out of 184 transfusion episodes, 16.9% were deemed inappropriate.
- Fresh frozen plasma had the highest rate of inappropriate use (58%), followed by packed red blood cells (35.5%).
- No inappropriate cryoprecipitate transfusions were observed.
Conclusions:
- Blood component audits are vital for optimizing clinical practice.
- Adherence to transfusion guidelines can significantly reduce inappropriate blood product use in pediatric settings.
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