Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Pulmonary Embolism II: Diagnostic Studies and Interprofessional Care01:29

Pulmonary Embolism II: Diagnostic Studies and Interprofessional Care

Diagnosing Pulmonary EmbolismDiagnosing pulmonary embolism (PE) involves clinical assessment and advanced imaging tests. The preferred diagnostic tool is the spiral (helical) CT scan or CT angiography (CTA), which uses intravenous contrast media to visualize the pulmonary vasculature and identify emboli.A ventilation-perfusion (V/Q) scan is an alternative for patients unable to receive contrast media. This scan includes both perfusion and ventilation scanning. Perfusion scanning involves...
Bronsted-Lowry Acids and Bases02:58

Bronsted-Lowry Acids and Bases

The acid-base reaction class has been studied for quite some time. In 1680, Robert Boyle reported traits of acid solutions that included their ability to dissolve many substances, to change the colors of certain natural dyes, and to lose these traits after coming in contact with alkali (base) solutions. In the eighteenth century, it was recognized that acids have a sour taste, react with limestone to liberate a gaseous substance (now known to be CO2), and interact with alkalis to form neutral...
Acute Respiratory Failure-II01:21

Acute Respiratory Failure-II

Type I Respiratory Failure, or hypoxemic respiratory failure, occurs when the partial pressure of oxygen (PaO2) in arterial blood falls below 60 mmHg while breathing room air without a corresponding increase in arterial carbon dioxide levels (PaCO2). This condition highlights a significant impairment in the lungs' capacity to oxygenate the blood.
The underlying physiological abnormalities that contribute to hypoxemic respiratory failure include:
Acute Respiratory Failure-V01:29

Acute Respiratory Failure-V

The treatment for acute respiratory failure varies based on factors like the underlying cause, overall health, and severity. A collaborative healthcare team is essential for early detection, often through arterial blood gas analysis. Identifying the cause is the primary goal, with treatment strategies adjusted for ventilation/perfusion (V/Q) mismatch, shunting, or diffusion impairment.
Ensure that patients are monitored continuously for their response to therapy, including changes in...
Acute Respiratory Failure-III01:30

Acute Respiratory Failure-III

Hypercapnic respiratory failure, also known as Type 2 or ventilatory respiratory failure, is a severe condition characterized by the body's inability to effectively remove carbon dioxide (CO2) from the bloodstream. It leads to an arterial CO2 pressure (PaCO2) exceeding 45 mmHg and a blood pH above 7.35. This situation indicates that the body's ventilatory demand, or the ventilation needed to maintain normal PaCO2 levels, surpasses its supply or the maximum gas flow achievable without causing...
Cardiopulmonary Resuscitation II: ACLS Airway Management01:22

Cardiopulmonary Resuscitation II: ACLS Airway Management

Airway management is a key skill in emergency and critical care settings, as maintaining a clear airway is essential for adequate oxygenation and ventilation.Head Tilt-Chin Lift TechniqueThe head tilt-chin lift maneuver is an essential technique primarily used in patients without suspected cervical spine injuries. To perform this maneuver, one hand is placed on the patient’s forehead, and gentle pressure is applied backward to tilt the head. The fingertips of the other hand are positioned under...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Effect of COVID-19 vaccination and SARS-CoV-2 infection status on mortality risk in patients with chronic obstructive pulmonary disease: a nationwide population-based cohort study.

Respiratory research·2026
Same author

Incidence and risk factors for idiopathic pulmonary fibrosis in individuals aged 75 years and older in an ultra-aging society.

Therapeutic advances in respiratory disease·2025
Same author

Impact of Quitting Smoking at Diagnosis on Overall Survival in Lung Cancer Patients: A Comprehensive Meta-Analysis.

Cancers·2025
Same author

Asthma Increases Long-Term Risk of Death by Suicide: A Nationwide Population-Based Cohort Study.

The journal of allergy and clinical immunology. In practice·2024
Same author

The impact of pulmonary tuberculosis on SARS-CoV-2 infection: a nationwide cohort study.

Frontiers in medicine·2024
Same author

Chronic periodontitis and risk of lung cancer: a nationwide cohort study.

Frontiers in oncology·2024

Related Experiment Video

Updated: May 17, 2026

Halogenated Agent Delivery in Porcine Model of Acute Respiratory Distress Syndrome via an Intensive Care Unit Type Device
09:36

Halogenated Agent Delivery in Porcine Model of Acute Respiratory Distress Syndrome via an Intensive Care Unit Type Device

Published on: September 24, 2020

Critical care paper review 2012.

Jang Won Sohn1

  • 1Department of Internal Medicine, Hanyang University College of Medicine, Seoul, Korea.

Tuberculosis and Respiratory Diseases
|October 27, 2012
PubMed
Summary

Recent sepsis drug trials failed, highlighting the need for new approaches. Understanding sepsis-induced immunosuppression and exploring novel therapies like ECMO are crucial for improving patient outcomes.

Area of Science:

  • Critical care medicine
  • Immunology
  • Infectious diseases

Background:

  • Sepsis care has improved, but recent drug development has stalled.
  • Two major drug trials (eritoran tetrasodium and drotrecogin alfa) failed to improve sepsis mortality.
  • Sepsis is associated with immunosuppression, but its characteristics in humans are poorly understood.

Purpose of the Study:

  • To highlight the urgent need for novel therapeutic strategies in sepsis management.
  • To emphasize the importance of understanding sepsis-induced immunosuppression.
  • To discuss the emerging role of extracorporeal membrane oxygenation (ECMO) in severe respiratory failure.

Main Methods:

  • Review of recent clinical trial outcomes for sepsis drugs.
  • Analysis of emerging research on sepsis-associated immunosuppression.
Keywords:
Critical CareExtracorporeal Membrane OxygenationReviewSepsis

More Related Videos

Observational Study Protocol for Repeated Clinical Examination and Critical Care Ultrasonography Within the Simple Intensive Care Studies
10:38

Observational Study Protocol for Repeated Clinical Examination and Critical Care Ultrasonography Within the Simple Intensive Care Studies

Published on: January 16, 2019

Evaluation of Capnography Sampling Line Compatibility and Accuracy when Used with a Portable Capnography Monitor
07:51

Evaluation of Capnography Sampling Line Compatibility and Accuracy when Used with a Portable Capnography Monitor

Published on: September 29, 2020

Related Experiment Videos

Last Updated: May 17, 2026

Halogenated Agent Delivery in Porcine Model of Acute Respiratory Distress Syndrome via an Intensive Care Unit Type Device
09:36

Halogenated Agent Delivery in Porcine Model of Acute Respiratory Distress Syndrome via an Intensive Care Unit Type Device

Published on: September 24, 2020

Observational Study Protocol for Repeated Clinical Examination and Critical Care Ultrasonography Within the Simple Intensive Care Studies
10:38

Observational Study Protocol for Repeated Clinical Examination and Critical Care Ultrasonography Within the Simple Intensive Care Studies

Published on: January 16, 2019

Evaluation of Capnography Sampling Line Compatibility and Accuracy when Used with a Portable Capnography Monitor
07:51

Evaluation of Capnography Sampling Line Compatibility and Accuracy when Used with a Portable Capnography Monitor

Published on: September 29, 2020

  • Compilation of clinical experiences with ECMO for ARDS.

    • Main Results:

    • Failure of eritoran and drotrecogin alfa trials indicates limitations of current therapeutic targets.
    • Evidence suggests sepsis can induce significant immunosuppression, necessitating further research.
    • Extracorporeal membrane oxygenation (ECMO) is increasingly utilized for severe respiratory failure, including H1N1-induced ARDS.

    Conclusions:

    • New therapeutic strategies beyond targeting inflammation are required for sepsis.
    • Further research into sepsis-induced immunosuppression is critical for developing effective treatments.
    • ECMO represents a viable option for managing severe respiratory failure in sepsis patients.