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Related Concept Videos

Formation of the Platelet Plug01:22

Formation of the Platelet Plug

The platelet phase, the second stage of hemostasis, commences around 15-20 seconds after an injury. It follows and overlaps with the vascular phase, during which blood vessels constrict to minimize blood loss.
As the injured blood vessel contracts, endothelial cells undergo contraction, revealing collagen fibers in the basement membrane and underlying connective tissue. Furthermore, the plasma membrane of endothelial cells becomes adhesive, preparing the site for platelet adhesion. Platelets...
Venous Thrombosis III: Interprofessional Care01:29

Venous Thrombosis III: Interprofessional Care

Venous thrombosis requires effective prevention and treatment strategies to improve patient outcomes and reduce potential complications.Prevention StrategiesHealthcare providers must prioritize preventing venous thromboembolism (VTE) for all adult patients upon admission. Interventions depend on bleeding and thrombosis risk, medical history, current medications, diagnoses, planned procedures, and patient preferences. Patients on bed rest should change positions every two hours and, if not...
Structure and Function of Platelets01:18

Structure and Function of Platelets

The cell fragments known as platelets are disc-shaped, with an average diameter of about 3 μm and a thickness of roughly 1 μm. They play a crucial role in the body's vascular clotting system, which also involves plasma proteins, blood cells, and blood vessel tissues.
Platelets are continually replenished, circulating in the bloodstream for 9-12 days before being removed by phagocytes, primarily in the spleen. A microliter of circulating blood contains between 150,000 and 450,000 platelets, with...
Pulmonary Embolism II: Diagnostic Studies and Interprofessional Care01:29

Pulmonary Embolism II: Diagnostic Studies and Interprofessional Care

Diagnosing Pulmonary EmbolismDiagnosing pulmonary embolism (PE) involves clinical assessment and advanced imaging tests. The preferred diagnostic tool is the spiral (helical) CT scan or CT angiography (CTA), which uses intravenous contrast media to visualize the pulmonary vasculature and identify emboli.A ventilation-perfusion (V/Q) scan is an alternative for patients unable to receive contrast media. This scan includes both perfusion and ventilation scanning. Perfusion scanning involves...
Introduction to Hemostasis01:05

Introduction to Hemostasis

Hemostasis is a complex physiological process that prevents excessive bleeding when a blood vessel is injured. It's crucial for maintaining the integrity of the circulatory system, as it ensures that our blood remains fluid while still within the vascular network and yet clots to prevent blood loss upon vessel injury.
The three phases of hemostasis involve many clotting factors present in plasma and several substances released by platelets and injured tissue cells. It is a fast, localized, and...
Anticoagulant Drugs: Low-Molecular-Weight Heparins01:30

Anticoagulant Drugs: Low-Molecular-Weight Heparins

Hemostasis is a crucial process that prevents excessive blood loss from damaged blood vessels. It involves various mechanisms such as vasoconstriction, platelet adhesion and activation, and fibrin formation. The importance of each mechanism depends on the type of vessel injury. In contrast, thrombosis is the abnormal formation of a blood clot within the blood vessels, leading to potential complications if the clot obstructs blood flow. Thrombosis can be caused by increased coagulability of the...

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Related Experiment Video

Updated: May 17, 2026

Preparation, Procedures and Evaluation of Platelet-Rich Plasma Injection in the Treatment of Knee Osteoarthritis
14:38

Preparation, Procedures and Evaluation of Platelet-Rich Plasma Injection in the Treatment of Knee Osteoarthritis

Published on: January 4, 2019

Platelet-rich plasma and the upper extremity.

Allan Mishra1, Pietro Randelli, Cameron Barr

  • 1Department of Orthopaedic Surgery, Menlo Medical Clinic, Stanford University Medical Center, 1300 Crane Street, Menlo Park, CA 94025, USA. am@totaltendon.com

Hand Clinics
|October 30, 2012
PubMed
Summary

Platelet-rich plasma (PRP) shows promise for tendon healing, particularly for tennis elbow. However, results for rotator cuff injuries are mixed, depending on PRP type and treatment methods.

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Last Updated: May 17, 2026

Preparation, Procedures and Evaluation of Platelet-Rich Plasma Injection in the Treatment of Knee Osteoarthritis
14:38

Preparation, Procedures and Evaluation of Platelet-Rich Plasma Injection in the Treatment of Knee Osteoarthritis

Published on: January 4, 2019

A Simple Double Centrifugation Tube Method to Obtain Platelet-rich Plasma from Equine Blood
06:10

A Simple Double Centrifugation Tube Method to Obtain Platelet-rich Plasma from Equine Blood

Published on: August 15, 2025

Area of Science:

  • Orthopedics
  • Regenerative Medicine
  • Biologics

Background:

  • Platelet-rich plasma (PRP) is derived from whole blood and concentrated with growth factors.
  • Preclinical data suggest PRP's potential in tendon repair and regeneration.
  • Clinical research has investigated PRP for chronic lateral epicondylar tendinopathy and rotator cuff pathology.

Purpose of the Study:

  • To explore the scientific rationale behind using PRP for orthopedic conditions.
  • To review the different formulations of PRP and their applications.
  • To analyze emerging clinical data on PRP efficacy and discuss future potential uses.

Main Methods:

  • Review of preclinical studies on PRP for tendon repair.
  • Analysis of controlled clinical trials focusing on chronic lateral epicondylar tendinopathy (tennis elbow).
  • Evaluation of studies investigating PRP for rotator cuff pathology, considering variations in PRP formulation, surgical techniques, and tear characteristics.

Main Results:

  • Multiple controlled studies support PRP's effectiveness in treating chronic tennis elbow.
  • Clinical outcomes for rotator cuff injuries treated with PRP have been inconsistent.
  • Variability in results may be attributed to differences in PRP preparation, surgical approaches, and the severity of tendon tears.

Conclusions:

  • PRP demonstrates efficacy for certain tendinopathies like tennis elbow.
  • Further research is needed to optimize PRP formulations and treatment protocols for rotator cuff repair.
  • PRP holds potential for broader applications in musculoskeletal regeneration.