Volumetric motion quantification by 3D tissue phase mapped CMR.

Area of Science:

• Cardiovascular Imaging
• Medical Physics
• Cardiac Mechanics

Background:

• Current myocardial motion quantification using tissue phase mapping (TPM) primarily relies on 2D acquisitions, limiting assessment to specific slices and excluding large regions of the left ventricle.
• Volumetric assessment of myocardial motion is crucial for a comprehensive understanding of cardiac mechanics and improving the diagnosis and treatment of myocardial motion abnormalities.

Purpose of the Study:

• To quantify myocardial motion across the entire left ventricle using 3D tissue phase mapped cardiac magnetic resonance imaging (3D-TPM CMR).
• To evaluate the feasibility of 3D-TPM for assessing volumetric myocardial motion and identifying motion abnormalities.

Main Methods:

• A black-blood 3D TPM sequence was employed for volumetric motion quantification in 12 healthy volunteers and 2 patients.
• Analysis included evaluating motion patterns between apical and basal locations and asynchronous motion between myocardial segments.
• Quantification parameters encompassed velocity, torsion, rotation angle, and strain.

Main Results:

• 3D-TPM successfully enabled the calculation of all investigated motion quantification parameters.
• Parameters indicative of hypokinetic or asynchronous motion effectively differentiated between healthy and impaired myocardium.

Conclusions:

• Three-dimensional tissue phase mapping (3D-TPM) provides gapless, volumetric quantification of left ventricular motion abnormalities.
• This technique offers valuable additional information for a more detailed analysis of left ventricular function in clinical applications.