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Eudragit: a technology evaluation.

Seema Thakral1, Naveen K Thakral, Dipak K Majumdar

  • 1GVM College of Pharmacy, Sonipat, India.

Expert Opinion on Drug Delivery
|October 30, 2012
PubMed
Summary
This summary is machine-generated.

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Eudragits are versatile polymethacrylate copolymers used in drug delivery. Different grades offer tailored solutions for enteric coating, colon targeting, sustained release, and taste masking, enhancing therapeutic efficacy.

Area of Science:

  • Polymer Science and Pharmaceutical Technology

Background:

  • Eudragit encompasses a range of polymethacrylate-based copolymers, including anionic, cationic, and neutral types.
  • These polymers are derived from methacrylic acid and methacrylic/acrylic esters or their derivatives.

Purpose of the Study:

  • To review the physicochemical characteristics and applications of various Eudragit grades.
  • Focus on applications in colon-specific, enteric-coated, and sustained-release drug delivery systems.
  • Explore the use of Eudragits in taste masking pharmaceutical formulations.

Main Methods:

  • Literature review of Eudragit physicochemical properties.
  • Analysis of Eudragit applications in different drug delivery systems.
  • Evaluation of Eudragit performance in taste masking.

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Main Results:

  • Eudragits are amorphous, non-biodegradable, nonabsorbable, and non-toxic polymers.
  • Anionic Eudragit L (pH > 6) and Eudragit S (pH > 7) are used for enteric coating and colon targeting.
  • Combinations of Eudragit L and S can ensure drug release at pH < 7, addressing limitations in colon targeting.
  • Water-insoluble Eudragit RL and RS are suitable for sustained-release film coating.
  • Cationic Eudragit E (insoluble at pH ≥ 5) is effective for taste masking.

Conclusions:

  • Eudragits offer tunable properties for advanced drug delivery.
  • Specific grades are optimized for pH-dependent drug release and controlled dissolution.
  • Eudragit polymers provide effective solutions for enteric coating, colon targeting, sustained release, and taste masking.