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Glyceryl trinitrate ointment did not reduce pain after stapled hemorrhoidectomy: a randomized controlled trial
Trent Cross1, Lynne Bartlett, Chrispen Mushaya
1Australian Institute of Tropical Medicine, within the North Queensland Centre for Cancer Research, James Cook University, Townsville, Australia.
International Surgery
|October 30, 2012
Summary
Topical glyceryl trinitrate (GTN) did not reduce pain after stapled hemorrhoidectomy. While effective for excisional hemorrhoidectomy, GTN did not improve pain or complications in this study.
Area of Science:
- Colorectal Surgery
- Pharmacology
Background:
- Topical glyceryl trinitrate (GTN) is known to alleviate anal spasm and pain post-hemorrhoidectomy.
- Its efficacy following stapled hemorrhoidopexy requires further investigation.
Purpose of the Study:
- To evaluate the effectiveness of topical 0.2% glyceryl trinitrate (GTN) in managing postoperative pain and complications after stapled hemorrhoidopexy.
Main Methods:
- A comparative study involving patients with symptomatic grade 3/4 hemorrhoids undergoing stapled hemorrhoidopexy.
- Patients were assigned to either routine postoperative care or topical GTN treatment.
- Outcomes assessed included postoperative pain, pain duration, complications, and patient satisfaction.
Main Results:
- The group receiving GTN reported higher maximum pain levels compared to the control group (P = 0.015).
- No significant differences were observed in pain duration, complications, recurrence rates, or satisfaction scores between the groups.
- Sixteen patients in the GTN group were noncompliant due to side effects.
Conclusions:
- Topical glyceryl trinitrate (GTN) does not appear to reduce postoperative pain or improve outcomes after stapled hemorrhoidopexy.
- The potential side effects of GTN may impact patient compliance.
